Collier de Perles: Human Rei ("acceptor" sequence) IGK V-J REGION
Collier de Perles: Mouse K20 (MuVKK20) ("donor" sequence)
Collier de Perles: Humanized K20 (HuVKK20)
Human Rei ("acceptor" sequence) IGK V-J REGION
- Human amino acids are shown in red.
- Grafted mouse amino acids are shown in green.
- Amino acids restored by mutagenesis in amino acids coreesponding to the mouse sequence (designated as "backmutations") are shown in blue
Amino acids are shown in the one-letter abbreviation.
Hydrophobic amino acids (hydropathy index with positive value) and Tryptophan (W) found at a given position in more than 50 % of analysed IG and TR sequences are shown in blue.
All Proline (P) are shown in yellow.
The CDR-IMGT are limited by amino acids shown in squares, which belong to the neighbouring FR-IMGT.
Hatched circles or squares correspond to missing positions according to the IMGT unique numbering.
Arrows indicate the direction of the beta strands and their different designations in 3D structure.
This information has to be used carefully if not supported by experimental data.
Author: Lisa truong