Citing IMGT dynamic tools: Sanou G., Zeitoun G. et al. IMGT® at scale: FAIR, Dynamic and Automated Tools for Immune Locus Analysis, Nucleic Acids Research. 2025;,gkaf1024. doi: 10.1093/nar/gkaf1024 (Free Article) PMID: 41091930.
Program version: v. 

Add information about removed genes/alleles.
May 15th, 2025.

Add the possibility to obtain a gene table per strain (for mouse now and for other species later) and allotypes/isotypes for human.
September 25th, 2024.

Bibliographical references in alphabetic order, small design changes and addition of "NL" for non-localized gene.
June 14th, 2024.

Addition of 'Score for IMGT allele confirmation' as well as NCBI TPA accession numbers.
September 20th, 2023.

Implementation of the dynamic gene table.

Gene table legend:

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene, when the data have been confirmed by several studies.

Functionality is shown in parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.

IMGT allele confirmation: A scoring system is employed to indicate the number of IMGT/LIGM-DB reference sequences and other sequences from the literature in which an IG or TR gene allele has been identified and annotated.

Removed genes/alleles
If a gene/allele existence or name has to be changed, the old name or gene/allele would be deleted and its name won't be reused. They are kept in the gene table for historical reasons.
A single star ()
indicates that an IG or TR gene allele is annotated in the reference sequence only.
Two stars ()
indicate that an IG or TR gene allele is annotated in its reference sequence and in one sequence from the literature.
Three stars ()
indicate that an IG or TR gene allele is annotated in its reference sequence and in at least two sequences from the literature.
In the Excel file, the stars are represented by the plus symbol (+).

Click on:
  • IMGT gene name to get the corresponding IMGT/GENE-DB entry (link).
  • IMGT allele name to see the corresponding Alignments of alleles (link).
  • Accession number to get the corresponding IMGT/LIGM-DB entry (link).
  • MAP: mapped sequences. Click to access GENE-DB «LOCALIZATION IN GENOME ASSEMBLIES» (link).
  • [number] to access the corresponding IMGT reference (popover).
  • (number) to see the corresponding IMGT note (popover).
Options:
  • You can show/hide columns (), download data () or put the table in fullscreen () using buttons.
See also (IMGT Scientific chart):
Select a species and a IMGT group to get the gene table:
Only IMGT available species/group are shown in the drop-down list.
The gene table can take several seconds to appear, please be patient.

Polymorphism by duplication of the IGLC2 and/or IGLC3 genes has been described [11,13]. The RFLP (Restriction Fragment Length Polymorphism) alleles correspond to polymorphic 8-, 13-, 18-, 23-, 28-kb EcoRI fragments [11-13,18], which contain 2, 3, 4, 5, 6 genes, respectively. So far, only the IGLC2 and IGLC3 genes of the 8-kb EcoRI fragment have been sequenced [9].

Gene table of human (Homo sapiens) IGLC IMGT group:
IMGT gene nameIMGT allele nameScore for
IMGT allele
confirmation		FctChromosomosal
localization		ExonsR T PrIMGT/LIGM-DB reference sequencesIMGT/LIGM-DB sequences from the literature
Clone namesAccession
numbers		Positions
in the sequence		Secondary
accession
numbers		Clone namesAccession
numbers		Positions
in the sequence
IGLC1 IGLC1*01 (8,9) ORF (1) 22q11.2 C-REGION J00252 [8] (10) ° <1-312
IGLC1 IGLC1*02 (8,9) F 22q11.2 C-REGION
RTPr
++
 X51755 [15] MAP (11) 4008-4324 D87023 [10] (11) 20974-21290
IMGT000225 [4,11] ° 879300-879616
IMGT000280 [13] ° 895317-895633
IMGT000293 [2,7] 891929-892245
IGLC2 IGLC2*01 (8,12) F 22q11.2 C-REGION J00253 [8] ° 30-346
IGLC2 IGLC2*02 (8,12) F 22q11.2 C-REGION
RTPr
++
 X06875 [14] ° MAP 98-414 D87023 [10] (11) 26575-26891
IMGT000225 [4,11] ° 884901-885217
IMGT000280 [13] ° 900918-901234
IMGT000293 [2,7] 902894-897845
X51754 [15] #g 7058-7374
X51755 [15] (11) 9601-9917
IGLC2 IGLC2*03 (8,12) F 22q11.2 C-REGION AJ491317 [12] (8) ° <1-106
IGLC2A IGLC2A*01 F 22q11.2 C-REGION IMGT000293 [2,7] 902894-903210
IGLC3 IGLC3*01 (8,13) F 22q11.2 C-REGION
RTPr
++
 J00254 [8] (10) ° <1-312
IGLC3 IGLC3*02 (8,13) F 22q11.2 C-REGION K01326 [9] ° 203-519
IGLC3 IGLC3*03 (8,13) F 22q11.2 C-REGION
RTPr
++
 X06876 [14] ° MAP 98-414 IMGT000225 [4,11] ° 890267-890583
IMGT000280 [13] ° 906284-906600
IMGT000293 [2,7] 908259-908575
X51755 [15] (11) 14989-15305
IGLC3 IGLC3*04 (8,12) F 22q11.2 C-REGION
RTPr
++
 D87017 [10] 3455-3771 D87023 [10] (11) 31931-32247
IGLC4 IGLC4*01 P (2) 22q11.2 C-REGION J03009 [6,8] (14) ° 2-303
IGLC4 IGLC4*02 P (3) 22q11.2 C-REGION X51755 [15] MAP (11) 19413-19716 D87017 [10] 7941-8190
IMGT000225 [4,11] ° 894699-895002
IMGT000280 [13] ° 910716-911019
IMGT000293 [2,7] 912691-912994
IGLC5 IGLC5*01 P (4) 22q11.2 C-REGION J03010 [6,8] ° 2-307
IGLC5 IGLC5*02 P (5) 22q11.2 C-REGION X51755 [15] MAP (11) 24267-24572 D87017 [10] 12737-13042
IMGT000225 [4,11] ° 899549-899854
IMGT000280 [13] ° 915567-915872
IMGT000293 [2,7] 917542-917847
X57808 [5] 1787-2092
IGLC6 IGLC6*01 (8,15) F 22q11.2 C-REGION
RTPr
++
 J03011 [6,8] ° 2-318
IGLC6 IGLC6*02 (16) P (6) 22q11.2 C-REGION X51755 [15] 28157-28478
IGLC6 IGLC6*03 (16) P (7) 22q11.2 C-REGION M61769 [1,6] ° 2-322 IMGT000293 [2,7] 921454-921774
IGLC6 IGLC6*04 (16) P (18) 22q11.2 C-REGION X57808 [5] MAP 5698-6018 IMGT000225 [4,11] ° 903460-903780
IMGT000280 [13] ° 919478-919798
IGLC6 IGLC6*05 (16) P (18) 22q11.2 C-REGION D87017 [10] 16650-16970
IGLC7 IGLC7*01 (8,17) F 22q11.2 C-REGION X51755 [15] MAP (11) 31201-31517 D87017 [10] 19709-20025
IMGT000280 [13] ° 922537-922853
X57808 [5] 8737-9053
IGLC7 IGLC7*02 (8,17) F 22q11.2 C-REGION M61771 [1] ° 2-318 IMGT000293 [2,7] 924513-924829
IGLC7 IGLC7*03 (8,17) F 22q11.2 C-REGION KM455557 [16] ° MAP 1-317 IMGT000225 [4,11] ° <906519->906835
IMGT notes: ↑
  1. because of none cDNA found
  2. Pseudogene due to DELETIONs leading to frameshifts in the C-REGION.
  3. Pseudogene due to DELETIONs leading to frameshifts
  4. Pseudogene due to a DELETION leading to a frameshift.
  5. Pseudogene due to a DELETION leading to a frameshift
  6. Pseudogene due to INSERTIONs leading to frameshifts
  7. Pseudogene due to an INSERTION of 4 bp leading to a frameshift
  8. Click here to see Correspondence between serological lambda isotypes and IGLC gene and alleles names.
  9. Serological marker: Mcg.
  10. Partial C-GENE in 5': 5 nucleotides missing.
  11. The IGLC1*02 is the EX3 of the conventional IGLL5*01 gene and allele (IGLL5 is a RPI gene that comprises three exons as identified in the X51755 and D87023 genomic sequences) (Gene and allele table: Human (Homo sapiens) IGLL)
  12. Serological markers: Ke- Oz-.
  13. Serological markers: Ke- Oz+.
  14. Partial C-GENE in 5': 2 nucleotides missing.
  15. Serological markers: Ke+ Oz-.
  16. The translation of the alleles *02 to *05 give a truncated lambda protein (premature STOP-CODON at position 88 as a result of the insertion (duplication) of 4 nucleotides which leads to a frameshift).
  17. IGLC7 encodes four of the five characteristic amino acids of the Ke+ Oz- isotype. However, it encodes a Lys at position 82 whereas all Ke+ Oz- myeloma proteins described to date contain a Thr at this position [4].
  18. Pseudogene due to INSERTIONs leading to frameshifts.
IMGT references: ↑
  1. Bauer T.R.Jr. and Blomberg B, The human lambda L chain Ig locus. Recharacterization of JC lambda 6 and identification of a functional JC lambda 7, J. Immunol, vol. 146, no. 8, 1991, pp. 2813-2820. PUBMED: 1901886
  2. Chu et al., Approaching an Error-Free Diploid Human Genome Assembly of East Asian Origin, (misc) bioRxivorg, 2025, DOI: 10.1101/2025.08.01.667781
  3. Chu et al., Direct Submission, Computational Biology, Beijing Institute of Genomics, Chinese Academy of Sciences / China National Center for Bioinformation. Submitted (16-AUG-2025). NGDC, Beijing, 100101, China.
  4. Cole,C.G. et al., Finishing the finished human chromosome 22 sequence, Genome Biol, vol. 9, no. 5, 2008, pp. R78-.
  5. Combriato G. and Klobeck H.G, V lambda and J lambda-C lambda gene segments of the human immunoglobulin lambda light chain locus are separated by 14 kb and rearrange by a deletion mechanism, Eur. J. Immunol, vol. 21, no. 6, 1991, pp. 1513-1522. PUBMED: 1904362
  6. Dariavach P. et al., Human immunoglobulin C lambda 6 gene encodes the Kern+Oz-lambda chain and C lambda 4 and C lambda 5 are pseudogenes, Proc. Natl. Acad. Sci. U.S.A, vol. 84, no. 24, 1987, pp. 9074-9078. PUBMED: 3122211
  7. He et al., T2T YAO: A Telomere to telomere Assembled Diploid Reference Genome for Han Chinese, Genomics Proteomics & Bioinformatics 21(6): 1085–1100 (2023), DOI: 10.1016/j.gpb.2023.08.001
  8. Hieter P.A. et al., Clustered arrangement of immunoglobulin lambda constant region genes in man, Nature, vol. 294, no. 5841, 1981, pp. 536-540. DOI: 10.1038/294536a0
  9. Hollis G.F. et al., Processed genes: a dispersed human immunoglobulin gene bearing evidence of RNA-type processing, Nature, vol. 296, no. 5855, 1982, pp. 321-325. DOI: 10.1038/296321a0
  10. Kawasaki K. et al., One-megabase sequence analysis of the human immunoglobulin lambda gene locus, Genome Res, vol. 7, no. 3, 1997, pp. 250-261. PUBMED: 9074928
  11. Lander,E.S. et al., Initial sequencing and analysis of the human genome, International Human Genome Sequencing Consortium Nature, vol. 409, no. 6822, 2001, pp. 860-921.
  12. Naud J.F. and Gibson D.M, A new coding region polymorphism of human IgLC2, Eur. J. Immunogenet, vol. 28, no. 1, 2001, pp. 97-99. DOI: 10.1046/j.1365-2370.2001.00239.x
  13. Nurk S. et al., The complete sequence of a human genome, Science, vol. 376, no. 6588, 2022, pp. 44-53. PUBMED: 35357919
  14. Udey J.A. and Blomberg B, Intergenic exchange maintains identity between two human lambda light chain immunoglobulin gene intron sequences, Nucleic Acids Res, vol. 16, no. 7, 1988, pp. 2959-2969. DOI: 10.1093/nar/16.7.2959
  15. Vasicek T.J. and Leder P, Structure and expression of the human immunoglobulin lambda genes, J. Exp. Med, vol. 172, no. 2, 1990, pp. 609-620. DOI: 10.1084/jem.172.2.609
  16. Watson C.T. et al., Sequencing of the human IG light chain loci from a hydatidiform mole BAC library reveals locus-specific signatures of genetic diversity, Genes Immun, vol. 16, no. 1, 2015, pp. 24-34. DOI: 10.1038/gene.2014.56