Domestic cat (Felis catus) TRB locus
- The domestic cat (Felis catus) TRB locus is on
chromosome A2. The orientation of the locus is forward (FWD).
- The domestic cat (Felis catus) TRB locus spans 302 kilobases (kb),
from 10 kb upstream of the most 5' gene in the locus, TRBV1 (F), to 10 kb downstream of the most 3' gene in the locus, TRBV30 (F).
The Locus representation encompasses 400 kb including the 5' borne MOXD2 and the 3' borne EPHB6.
- The domestic cat (Felis catus) TRB locus consists
of 33 TRBV genes belonging to 27 TRBV subgroups, 2 TRBD genes
belonging to 2 TRBD sets, 12 TRBJ genes belonging to 2 TRBJ sets
and 2 TRBC genes.
- The TRBV genes span 268
kilobases (kb), the TRBD genes span 4596 bases
(b), the TRBJ genes span 6609 bases (b) and
the TRBC genes span 12 kilobases (kb).
Clusters
- The TRBV genes are localized in 2 V-CLUSTER:
- the 5' V-CLUSTER, classically in 5' of the TRBD, TRBJ and
TRBC, includes 32 TRBV genes belonging to 26 subgroups (19 genes
are functional, 4 genes are ORF and 9 genes are pseudogenes).
- the 3' V-CLUSTER, downstream of the TRBC in inverted
orientation, includes 1 TRBV gene (functional).
- The TRBD, TRBJ and TRBC genes are localized in two
D-J-C-CLUSTER between the 5' V-CLUSTER and the 3' V-CLUSTER:
- the first D-J-C-CLUSTER, in 3' of the 5' V-CLUSTER,
includes 1 TRBD gene (functional), 6 TRBJ genes (3 genes are functional, 1 gene is ORF and 2 gene are pseudogene) and 1 TRBC
gene (functional).
- the second D-J-C-CLUSTER, in 5' of the 3' V-CLUSTER,
includes 1 TRBD gene (functional), 6 TRBJ genes (5 genes are
functional and 1 gene is pseudogene) and 1 TRBC gene (functional).
Bornes of the domestic cat (Felis catus) TRB locus
- MOXD2 (5' borne) has been identified 4324 b upstream of
TRBV1, the most 5' gene in the locus.
- EPHB6 (3' borne) has been identified 30 kb downstream of
TRBV30, the most 3' gene in the locus.
- Created:
- 19/02/2019
- Last updated:
- Friday, 22-Sep-2023 18:22:16 CEST
- Author:
- Viviane Nguefack Ngoune and Marie-Paule Lefranc
- Editor:
- Viviane Nguefack Ngoune and Marie-Paule Lefranc
