Naked mole-rat (Heterocephalus glaber) TRB locus on chromosome 22
- The Naked mole-rat (Heterocephalus glaber) TRB locus on chromosome 22.
The orientation of the locus is reverse (REV).
- The Naked mole-rat (Heterocephalus glaber) TRB locus spans 283 kilobases (kb),
from 10 kb upstream of the most 5' gene in the locus, TRBV4 (F), to 10 kb
downstream of the most 3' gene in the locus, TRBV30 (F).
The Locus representation
encompasses 400 kb including the 3' borne EPHB6.
- The Naked mole-rat (Heterocephalus glaber) TRB locus consists
of 29 TRBV genes belonging to 26 TRBV subgroups, 2 TRBD genes
belonging to 2 TRBD set, 13 TRBJ genes belonging to 2 TRBJ set, and
2 TRBC genes.
- The TRBV genes span 263
kilobases (kb), the TRBD genes span 3 kilobases
(kb), the TRBJ genes span 6 kilobases (kb) and
the TRBC genes span 11 kilobases (kb).
Clusters
- The TRBV genes are localized in 2 V-CLUSTER:
- the 5' V-CLUSTER, classically in 5' of the TRBD, TRBJ and
TRBC, includes 28 TRBV genes belonging to 25 subgroups (7 genes
are functional, 8 genes are ORF and 13 genes are pseudogenes).
- the 3' V-CLUSTER, downstream of the TRBC in inverted
orientation, includes 1 TRBV gene (functional).
- The TRBD, TRBJ and TRBC genes are localized in two
D-J-C-CLUSTER between the 5' V-CLUSTER and the 3' V-CLUSTER:
- the first D-J-C-CLUSTER, in 3' of the 5' V-CLUSTER,
includes 1 TRBD gene (functional), 6 TRBJ genes (3 genes are
functional and 3 gene are ORF) and 1 TRBC gene (functional).
The most C-proximal TRBJ gene, TRBJ1-6, being localized at
2328 bases in 5' of TRBC1.
- the second D-J-C-CLUSTER, in 5' of the 3' V-CLUSTER,
includes 1 TRBD gene (functional), 7 TRBJ genes (4 genes are
functional and 3 genes are ORF) and 1 TRBC gene (functional). The most C-proximal TRBJ gene,
TRBJ2-7, being localized at 2617 bases in 5' of TRBC2.
Bornes of the Naked mole-rat (Heterocephalus glaber) TRB locus
- EPHB6 (3' borne) has been identified 180 kb downstream of
TRBV30, the most 3' gene in the locus.
- Created:
- 25/05/2021
- Last updated:
- Tuesday, 06-Feb-2024 21:00:10 CET
- Author:
- Maria Georga, Ariadni Papadaki
