Rabbit (Oryctolagus cuniculus) TRB locus
- The rabbit (Oryctolagus cuniculus) TRB locus spans 530 kilobases (kb),
from 10 kb upstream of the most 5' gene in the locus, TRBV1 (F), to 10 kb
downstream of the most 3' gene in the locus, TRBV30 (F).
The Locus representation
encompasses 600 kb including the 5' borne MOXD2 and the 3' borne EPHB6.
- The rabbit (Oryctolagus cuniculus) TRB locus consists
of 77 TRBV genes belonging to 26 TRBV subgroups, 2 TRBD genes
belonging to 2 TRBD set, 12 TRBJ genes belonging to 2 TRBJ set, and
2 TRBC genes.
- The TRBV genes span 496
kilobases (kb), the TRBD genes span 4606 bases
(b), the TRBJ genes span 5029 bases (b) and
the TRBC genes span 14 kilobases (kb).
Clusters
- The TRBV genes are localized in 2 V-CLUSTER:
- the 5' V-CLUSTER, classically in 5' of the TRBD, TRBJ and
TRBC, includes 76 TRBV genes belonging to 25 subgroups (58-59 genes
are functional and 17-18 genes are pseudogenes).
- the 3' V-CLUSTER, downstream of the TRBC in inverted
orientation, includes 1 TRBV gene (functional).
- The TRBD, TRBJ and TRBC genes are localized in two
D-J-C-CLUSTER between the 5' V-CLUSTER and the 3' V-CLUSTER:
- the first D-J-C-CLUSTER, in 3' of the 5' V-CLUSTER,
includes 1 TRBD gene (functional), 6 TRBJ genes (5 genes are
functional and 1 gene is ORF) and 1 TRBC gene (functional).
The most C-proximal TRBJ gene, TRBJ1-6, being localized at
2.487 kilobases in 5' of TRBC1.
- the second D-J-C-CLUSTER, in 5' of the 3' V-CLUSTER,
includes 1 TRBD gene (functional), 6 TRBJ genes (functional)
and 1 TRBC gene (functional). The most C-proximal TRBJ gene,
TRBJ2-6, being localized at 3.865 kilobases in 5' of TRBC2.
Bornes of the rabbit (Oryctolagus cuniculus) TRB locus
- MOXD2 (5' borne) has been identified 3 kb upstream of
TRBV1, the most 5' gene in the locus.
- EPHB6 (3' borne) has been identified 51 kb downstream of
TRBV30, the most 3' gene in the locus.
- Created:
- 15/01/2019
- Last updated:
- Friday, 22-Sep-2023 18:22:18 CEST
- Author:
- Perrine Pégorier
