IMGT Repertoire (IG and TR)

Sumatran orangutan (Pongo abelii) TRD locus on chromosome 15

The Sumatran orangutan (Pongo abelii) TRD locus is on chromosome 15. The orientation of the locus is forward (FWD).
The Sumatran orangutan (Pongo abelii) TRA/TRD locus spans 1050 kilobases (kb), from 10 kb upstream of the most 5' gene in the locus, TRAV1-1 (F), to 10 kb downstream of the most 3' gene in the locus, TRAC (F). The Locus representation encompasses 1200 kb including the 5' borne OR10G3 and the 3' borne DAD1.
The Sumatran orangutan (Pongo abelii) TRD locus consists of 11 genes: 3 TRDV belonging to 3 subgroups, 3 TRDD genes, 4 TRDJ and a unique TRDC gene.
The TRDV genes span 38 kilobases (kb), the TRDD genes span 19 kilobases (kb), the TRDJ genes span 12 kilobases (kb) and the TRDC gene spans 6 kilobases (kb).

The TRDV genes are localized in 2 V-CLUSTER:
- the 5' V-CLUSTER, classically in 5' of the TRDD, TRDJ and TRDC, includes 2 TRDV genes belonging to 2 subgroups.
- the 3' V-CLUSTER, downstream of the TRDC in inverted orientation, includes 1 TRDV gene.
The TRDD, TRDJ and TRDC genes are localized in one D-J-C-CLUSTER between the 5' V-CLUSTER and the 3' V-CLUSTER:
- The CLUSTER includes 3 TRDD, 4 TRDJ and 1 TRDC.

OR10G3 (5' borne) has been identified 50 kb upstream of TRAV1-1, the most 5' gene in the locus.
DAD1 (3' borne) has been identified 12 kb downstream of TRAC, the most 3' gene in the locus.