IMGT Web resources: IMGT repertoire

Number of germline genes and potential repertoire: Human TRDV at 14q11.2

References:
Lefranc M.-P. et al. Res. Immunol., 141, 692-693 (1990).

3 TRDV genes belonging to 3 subgroups.
   TRDV1 at 360kb upstream of TRDC, among the TRAV genes.
   TRDV2 at 44 kb upstream of TRDC.
   TRDV3 at 3 kb dowstream of TRDC and in inverted orientation of transcription.

Potential repertoire: 3 FUNCTIONAL TRDV genes belonging to 3 subgroups
4-5 FUNCTIONAL TRAV/DV genes belonging to 4-5 subgroups

TRDV
Subgroup TRDV
gene name Functional ORF Pseudogene Total

1 TRDV1 1 - - 1

2 TRDV2 1 - - 1

3 TRDV3 1 - - 1

Total 3 0 0 3

5 TRAV/DV genes belonging to 5 subgroups (these genes are reported in Potentiel repertoire of Human TRAV at 14q11.2).
These genes have been found also rearranged either to D and J segments of the locus TRD or to TRAJ segments, and can therefore be used in the synthesis of delta or alpha chains.

* FUNCTIONAL or PSEUDOGENE

IMGT note:
(1) The TRAV38/DV8 subgroup comprises two genes, only the TRAV38-2/DV8 gene has so far been found rearranged to TRDD segments.

More information:
Gene table: human (Homo sapiens) TRDV
Gene table: human (Homo sapiens) TRDD
Gene table: human (Homo sapiens) TRDJ
Gene table: human (Homo sapiens) TRDC
Potential germline repertoire: human (Homo sapiens) TRAV genes on chromosome 14

Created: 30/06/2000
Last updated: Friday, 22-Sep-2023 18:22:31 CEST
Author: Marie-Paule Lefranc and Viviane Nguefack Ngoune