IG leader sequence logos:

TR leader sequence logos:

Leader sequences correspond to L-PART1 + L-PART2 artificially spliced. Sequences were extracted from IMGT/GENE-DB [1] with one sequence for each functional gene (allele *01). Number of gene sequences used to build the logo are indicated with, between parentheses, the number of subgroups to which the genes belong. Blanks in the sequences correspond to gaps introduced to maximize the alignment.

Leader sequence logos were generated using Weblogo [2].

Colors are according to the IMGT color menu for amino acid chemical characteristics classes [3].

IGHV IGKV IGLV TRAV TRBV TRGV TRDV
IMGT references:
[1] Giudicelli, V. et al., Nucl. Acids Res., 2005, 33, D256-D261. PMID: 15608191 LIGM:292 pdf
[2] Crooks, G.E. et al., Genome Research, 14, 1188-1190 (2004). PMID: 15173120
[3] Pommié, C. et al., Journal of Molecular Recognition, 17, 17-32 (2004). PMID: 14872534 LIGM:284 pdficon