When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated
in red letters.
Dashes indicate identical nucleotides. Dots indicate gaps by comparison to the longest
sequence. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).
The nucleotide between parentheses at the beginning of exons comes from a DONOR-SPLICE (n from ngt). The first nucleotide from an INT-DONOR-SPLICE is underlined (n from ngt).
Exon names are shown between parentheses on the first line.
The Cysteines involved in the IG CH1, CH2 and CH3 intrachain disulfide bridge are shown with a larger letter C in purple.
The Cysteines involved in the H-L or H-H interchain disulfide bridge are shown with a larger letter C in black.
STOP-CODON is indicated by an asterisk.
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).
Stump-tailed macaque (Macaca arctoides)
1 2 3 4 5 6 7 8
V P P P K P C L
AB013754,IGHA*01 (H) (1) (G)TT CCC CCA CCC AAG CCT TGC TTA
AB013755,IGHA*01 (-)-- --- --- --- --- --- --- ---
1.2 1.1 1 2
C D K P
AB013754,IGHA*01 (CH2) TGT GAC AAA CCC CG
AB013755,IGHA*01 --- --- --- --- --
Assam macaque (Macaca assamensis)
119 120 121 122 123
A V P C
AB013770,IGHA*01 (CH1) GCT GTG CCC TGC G
1 2 3 4 5 6 7 8 9 10
V L P P N S C L
AB013770,IGHA*01 (H) (1) TT CTC CCA CCC AAC TCT TGC TTA ... ...
S Q T K P
AB013753,IGHA*02 -- TC- -A- A-- --G C-- --- --- ... ...
P I T P P C P S
AB013762,IGHA*03 -- -C- --- AT- -CA C-C CCA -GT CCC TCA
P I T P P C P S
AB013763,IGHA*03 -- -C- --- AT- -CA C-C CCA -GT CCC TCA
1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
C D E P R L S L R R P A L
AB013770,IGHA*01 (CH2) TGT GAT GAA CCC CGA CTG TCG CTG CGC CGA CCA GCC CTC
K
AB013753,IGHA*02 --- --C A-- --- --
C
AB013762,IGHA*03 --C TGC --G --- --
C
AB013763,IGHA*03 --C TGC --G --- --
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
E D L L L G S E A N L T C T L T G L
AB013770,IGHA*01 (CH2) GAG GAC CTG CTC CTA ... ... GGT TCA GAA GCG AAC CTC ACG TGC ACA CTG ACC GGC CTG
_________BC_____________________
29 30 31 32 33 34 35 36
R D P S G A T
AB013770,IGHA*01 (CH2) AGA GAT CCC ... TCG GGT GCC ACC
Taiwan macaque (Macaca cyclopis)
119 120 121 122 123
A V P C
AB013766,IGHA*01 (CH1) GCT GTG CCC TGC G
1 2 3 4 5 6 7 8 9 10
V P P I T P P C P S
AB013766,IGHA*01 (H) (1) TT CCC CCA ATC ACA CCC CCA TGT CCC TCA
S Q T K C L
AB013756,IGHA*02 -- T-- -A- -C- -AG --T TGC -TA
1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
C C E P R L S L R R P A L
AB013766,IGHA*01 (CH2) TGC TGC GAG CCC CGA CTG TCG CTG CGC CGG CCG GCC CTC
D K
AB013756,IGHA*02 --T GA- A-A --- --
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
E D L L L G S E A N L T S T L T G L
AB013766,IGHA*01 (CH2) GAG GAC CTG CTC CTA ... ... GGT TCA GAA GCG AAC CTC ACG TCC ACA TTG ACA GGC CTG
_________BC_____________________
29 30 31 32 33 34 35 36
K D P S G A T
AB013766,IGHA*01 (CH2) AAA GAT CCC ... TCG GGT GCC ACC
Crab-eating macaque (Macaca fascicularis)
1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
A S P T R P K V F P L S L E G
X53705 ,IGHA*01 (CH1) (G)CA TCC CCG ACC AGA CCC AAG GTC TTC CCG CTG AGC CTC GAG GGC
X53389 ,IGHA*01 (-)-- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
T Q S D N V V V A C L V Q G F
X53705 ,IGHA*01 (CH1) ACC CAG ... ... ... ... ... TCA GAT AAC GTG GTC GTC GCC TGC CTG GTC CAG GGC TTC
X53389 ,IGHA*01 --- --- ... ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
_________BC_____________________ ___________CD_______
45.1 45.3 45.5
29 30 31 32 33 34 35 36 39 40 41 42 43 44 45 45.2 45.4
F P Q E P L N V T W S K S G A G V
X53705 ,IGHA*01 (CH1) TTC CCC CAG ... GAG CCA CTC AAC GTG ACC TGG AGC AAA AGC GGA GCG GGC GTG ... ...
X53389 ,IGHA*01 --- --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
________ _________________________DE_____________
45.7 84.1 84.3 84.5 84.7 85.6
45.6 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
T V I N F P P S Q D A S G
X53705 ,IGHA*01 (CH1) ... ... ACC GTC ATA AAC TTC CCG CCC AGC CAG GAC GCC TCC GGG ... ... ... ... ...
X53389 ,IGHA*01 ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ...
________________ _EF_____
85.4 85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98
G L Y T T S S Q L T L P A A Q C P A
X53705 ,IGHA*01 (CH1) GGC CTG TAC ACC ACG AGC AGC CAG CTG ACC CTG CCG GCC GCA CAG TGC ... ... CCA GCC
X53389 ,IGHA*01 --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- ---
_______________________FG___________________________
99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
R E S V T C H V E H Y T N P S Q D
X53705 ,IGHA*01 (CH1) AGG GAG TCC GTG ACA TGC CAC GTG GAG CAC TAC ... ... ... ACG AAT CCC AGC CAG GAT
X53389 ,IGHA*01 --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- --- --- --- ---
119 120 121 122 123
V A V P C
X53705 ,IGHA*01 (CH1) GTG GCC GTG CCC TGC G
X53389 ,IGHA*01 --- --- --- --- --- -
1 2 3 4 5 6 7 8 9 10
V S E T K P C L
X53705 ,IGHA*01 (H) (1) TT TCC GAA ACC AAG CCT TGC TTA ... ...
X53389 ,IGHA*01 -- --- --- --- --- --- --- --- ... ...
P P P N S
AB013758,IGHA*02 -- C-- CC- C-- --C T-- --- --- ... ...
P P I T P C P S
AB013764,IGHA*03 -- C-- CC- -T- -CA --C CCA -GT CCC TCA
1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
C D K P R L S L R R P A L
X53705 ,IGHA*01 (CH2) TGT GAC AAA CCC CGA CTG TCA CTG CGC CGG CCG GCC CTC
X53389 ,IGHA*01 --- --- --- --- --- --- --- --- --- --- --- --- ---
AB013758,IGHA*02 --- --- --- --- --
C E
AB013764,IGHA*03 --C TG- G-G --- --
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
E D L L L G S E A N L T C T L T G L
X53705 ,IGHA*01 (CH2) GAG GAC CTG CTC CTA ... ... GGT TCA GAA GCG AAC CTC ACG TGC ACA CTG ACC GGC CTG
X53389 ,IGHA*01 ---
_________BC_____________________ ___________CD_______
45.1 45.3 45.5
29 30 31 32 33 34 35 36 39 40 41 42 43 44 45 45.2 45.4
R N P S G A T F T W T P S S G K N
X53705 ,IGHA*01 (CH2) AGA AAT CCC ... TCG GGT GCC ACC TTC ACC TGG ACG CCC TCA AGT GGG AAG AAC ... ...
________ _________________________DE_____________
45.7 84.1 84.3 84.5 84.7 85.6
45.6 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
A V Q Q S P K R D P C G
X53705 ,IGHA*01 (CH2) ... ... GCT GTC CAA CAG TCA CCT AAG CGT GAC CCC TGT GGC ... ... ... ... ... ...
________________ _EF_____
85.4 85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98
C Y S V S S V L P G C A E P W N N
X53705 ,IGHA*01 (CH2) ... TGC TAC AGT GTG TCC AGT GTC CTG CCC GGC TGT GCC GAG CCA TGG ... ... AAC AAT
_______________________FG___________________________
99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
R V T F T C T A E H P E L E T Q L T
X53705 ,IGHA*01 (CH2) AGG GTG ACC TTC ACC TGC ACT GCT GAG CAC CCT GAG ... ... TTG GAG ACC CAA CTA ACT
119 120 121 122 123 124
A T I S K P
X53705 ,IGHA*01 (CH2) GCC ACC ATC TCA AAA CCC G
1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
G N T F R P E V H L L P P P S
X53705 ,IGHA*01 (CH3) GA AAC ACA TTC CGG CCC GAG GTC CAC CTG CTG CCG CCG CCG TCG
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
E E L A L N E L V T L T C L A R G F
X53705 ,IGHA*01 (CH3) GAG GAG CTG GCC CTG ... ... AAC GAG CTG GTG ACG CTG ACG TGC CTG GCA CGC GGC TTC
_________BC_____________________ ___________CD_______
45.1 45.3 45.5
29 30 31 32 33 34 35 36 39 40 41 42 43 44 45 45.2 45.4
S P E D V L V R W L K G T E Q L P R
X53705 ,IGHA*01 (CH3) AGC CCC ... ... GAG GAT GTG CTG GTT CGC TGG CTG AAG GGA ACA GAA CAG CTG CCC CGT
________ _________________________DE_____________
45.7 84.1 84.3 84.5 84.7 85.6
45.6 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
D K Y L T W E S R K E P S Q G T
X53705 ,IGHA*01 (CH3) GAC ... AAG TAC CTG ACT TGG GAA TCC CGG AAG GAG CCC AGC CAG GGC ... ... ... ACC
________________ _EF_____
85.4 85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98
T T F A V T S I L R V A A E D W K K
X53705 ,IGHA*01 (CH3) ACC ACC TTC GCC GTG ACC AGC ATA CTG CGC GTG GCA GCC GAG GAC TGG ... ... AAG AAG
_______________________FG___________________________
99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
G D T F S C M V G H E A L P L A F T Q
X53705 ,IGHA*01 (CH3) GGG GAC ACC TTC TCC TGC ATG GTG GGC CAC GAG GCC ... CTG CCG CTG GCC TTC ACA CAG
____________________________________CHS
119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138
K T I D R L A G K P T H V N V S V
X53705 ,IGHA*01 (CH3) AAG ACC ATC GAC CGC CTG GCG ... ... ... GGT AAA CCC ACC CAC GTC AAT GTG TCT GTG
________________________________________
139 140 141 142 143 144 145 146 147 148
V M A E V D G T C Y *
X53705 ,IGHA*01 (CH3) GTC ATG GCG GAA GTG GAC GGC ACC TGC TAC
Pig-tailed macaque (Macaca nemestrina)
119 120 121 122 123
A V P C
AB013765,IGHA*01 (CH1) GCT GTG CCC TGC G
AB013771,IGHA*02 --C --- --- --- -
1 2 3 4 5 6 7 8 9 10
V P P I T P P C P S
AB013765,IGHA*01 (H) (1) TT CCC CCA ATC ACA CCC CCA TGT CCC TCA
S Q T K C L
AB013771,IGHA*02 -- T-- -A- -C- -AG --T TGC -TA
1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
C C E P R L S L R R P A L
AB013765,IGHA*01 (CH2) TGC TGC GAG CCC CGA CTG TCG CTG CGC CGG CCG GCC CTC
D K
AB013771,IGHA*02 --T GA- A-A --- --- --- --A --- --- --- --- --- ---
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
E D L L L G S E A N L T C T L T G L
AB013765,IGHA*01 (CH2) GAG GAC CTG CTC CTA ... ... GGT TCA GAA GCG AAC CTC ACG TGC ACA CTG ACC GGC CTG
AB013771,IGHA*02 --- --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
_________BC_____________________
29 30 31 32 33 34 35 36
R D P S G A T
AB013765,IGHA*01 (CH2) AGA GAT CCC ... TCG GGT GCC ACC
N
AB013771,IGHA*02 --- A-- --- ... --- --- --- ---
Liontail macaque (Macaca silenus)
119 120 121 122 123
A V P C
AB013775,IGHA*01 (CH1) GCC GTG CCC TGC G
1 2 3 4 5 6 7 8
V S Q T K P C L
AB013775,IGHA*01 (H) (1) TT TCC CAA ACC AAG CCT TGC TTA
1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
C D K P R L S L R R P A L
AB013775,IGHA*01 (CH2) TGT GAC AAA CCC CGA CTG TCG CTG CGC CGG CCG GCC CTC
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
E D L L L G S E A N L T C T L T G L
AB013775,IGHA*01 (CH2) GAG GAC CTG CTC CTA ... ... GGT TCA GAA GCG AAC CTC ACG TGC ACA TTG ACC GGC CTG
_________BC_____________________
29 30 31 32 33 34 35 36
R N P S G A T
AB013775,IGHA*01 (CH2) AGA AAT CCC ... TCG GGT GCC ACC
Pere David's macaque (Macaca thibetana)
1 2 3 4 5 6 7 8
V P P P K P C L
AB013752,IGHA*01 (H) (1) (G)TT CCC CCA CCC AAG CCT TGC TTA
1.2 1.1 1 2
C D K P
AB013752,IGHA*01 (CH2) TGT GAC AAA CCC CG
IMGT note:
(1) In the IGHA gene, the hinge (H) and the (CH2) are joined in a single exon.
Created: 04/11/2002
Author: Nathalie Bosc
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