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Citing this page:
Lefranc, M.-P. and Lefranc, G. Human Gm, Km and Am allotypes and their molecular characterization: a remarkable demonstration of polymorphism In: B. Tait, F. Christiansen (Eds.), Immunogenetics, chap. 34, Humana Press, Springer, New York, USA. Methods Mol. Biol. 2012; 882, 635-680. PMID: 22665258

Em allotype

Em1 allotype

One allotype marker, Em1, was reported on human IgE Fc [1]

The correlation between the allotype Em1 and the corresponding amino acid change has not been identified. Therefore the IGHE polymorphism can only be analysed at the molecular sequence level [2,3] Alignments of alleles: human (Homo sapiens) IGHE.

IGHE allele names and sequence polymorphisms

IGHE allele names (nt) Amino acid positions (1)
Exons CH1 CH4-CHS M
IMGT unique numbering 41 41 111 37
Exon numbering (43) (41) (37)
IGHE*01 C
(Cys)
tgc		 W
(Trp)
tgg		 A
(Ala)
gcg		 L
(Leu)
ctc
IGHE*02 W
(Trp)
tgg		 W
(Trp)
tgg		 A
(Ala)
gcg		 nd
IGHE*03 C
(Cys)
tgc		 L
(Leu)
ttg		 A
(Ala)
gcg		 L
(Leu)
ctc
IGHE*04 W
(Trp)
tgg		 W
(Trp)
tgg		 A
(Ala)
gca		 I
(Ile)
atc

IMGT notes:
(1) Amino acid numbering in bold is according to IMGT unique numbering for C-DOMAIN [4], and between parentheses: exon numbering [2].
IMGT references:
[1] van Loghem, E., Aalberse, R.C., Matsumoto, H. A genetic marker of human IgE heavy chains, Em(1). Vox Sang., 46(4), 195-206 (1984). PMID:6201004
[2] Lefranc G. and Lefranc M.-P. The Immunoglobulin FactsBook, Academic press, London, UK, 458 pages (2001).
[3] Lefranc M-P. Immunoglobulin (IG) and T cell receptor genes (TR): IMGT® and the birth and rise of immunoinformatics. Front Immunol. 2014 Feb 05;5:22. doi: 10.3389/fimmu.2014.00022. Open access.PMID: 24600447 LIGM:429
[4] Lefranc, M.-P. et al., IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains. Dev. Comp. Immunol., 29, 185-203 (2005). PMID: 15572068 pdf with permission from Elsevier LIGM:293

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