Protein display: Spotted ratfish (Hydrolagus colliei) IGH C-REGIONs

The IGHC protein display numbering is according to the IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.

Only the *01 allele of each functional, ORF and in-frame pseudogenes C-REGION is shown.

N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).

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      IGHC
      genes

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                                  A                 B         BC         C               D                     E              F               G
                            --------------->    ---------->             ----->        ----------->       -------------->  ------------->   ---------->

                             1       10   15  16  20 23      30    36 39 41 45      77     84             85  89     96 97    104   110 114   120       130       140       150
                      7654321|........|....|123|...|...... ...|.....|  |.....|1234567|......|12345677654321|..........|12|............|...|.....|.........|.........|.........|
CH1
AF003844,IGHM1*01  (D)IVKPKPSPPVVILLQPSAEDIAM..LRPATAVCLIF SFEP..DKLS  VKWLKNWQPVTS..GVVTSPSVKEDN......GTFSISSRLTVPAREW..RNGGVYICQVSHS....PTDTTIVKSITMPT
AF003862,IGHM2*01      (A)VPTPPSLYALLPSCGPSTS..RGSVTFWCLAT NYNP..EPAT  FSWTSNGRSITD..QVKTYPSVLNKN......GLYTLSSQLTIAESQM...DNSNIRCKVKSS....SWPDVDIPLP
AF003839,IGHM3*01c     (A)TPTAPSLYALLPTCGSPPL..EGQLTFGCLAA DFSP..EPAT  FSWTSKGHPIAN..KGQVKSYPPVLSK....AGFYTASSQLTIEASQV...DIFNLCCQVKSS....IWLDGDICFP
AF004359,IGHM4*01c     (A)VPTPPSLYALLPSCGPSTS..RGSVTFWCLAT NYNP..EPAT  FSWTSNGRSITD..QVKTYPSVLNKN......GLYTLSSQLTIAESQM...DNSNIRCKVKSS....SWPDVDTPLP
AF004360,IGHM5*01c     (A)VPTPPSLYALLPSCGPSTS..RGSVTFWCLAT NYNP..EPAT  FSWTSNGRSITD..QVKTYPSVLNKN......GLYTLSSQLTIAESQM...DNSNIRCKVKSS....SWPDVDIPLP
AF003853,IGHM8*01c (D)IVKPKPSPPGVILLPPSPEDMAM..LRPATAVCLIF SFEP..DKLS  VKWFKDWQPVTS..GVVTSPSVKEDN......GTYSISSRLTVPAREW..RNGGVYICQVSHS....PTDTTIVQSITMPT

CH2
AF003845,IGHM1*01  (V)DEIQEPSPPVVILTQPSPEDIAI..HKPGIAVCLIS GFRP..DELT  VKWLKDWEPITS..GVETSPSVKEDN......GTFTTSSRLTVLAREW..RSGSVYTCQVSHS....PTQTYIVKNITKSS
AF003863,IGHM2*01  (V)ELLQDPSPPVVILTQTSPEDITL..NKQATAVCLIS SFRP..DKLR  VDWLKDWQIITS..GVVTSLSVKEDN......GTFSTSSRLTVPARDW..RNDTVYTCQVTHV....PTQTIIVKNITKSS
AF003839,IGHM3*01c    (V)VQPSPPVVLLTQTSPEDIAL..INQATLLCSVS GFRP..DKLI  VDWLKDGKAVTS..GIETSPSLKDN...... GNFSTDSRLTIPAKDW..RWDVVYSCRVTHD....PSQTLIIKNITNWNP
AF004359,IGHM4*01c (V)ELLQAPSPPVVILTQTSPEDITL..NKQATAVCLIS SFRP..DKLR  VDWLKDWQIVTS..GVVTSLSVKEDN......GTFSTSSRLTVPARDW..RNDAVYTCQVTHV....PTQTIIVKNITKSS
AF004360,IGHM5*01c (V)ELLQDPSPPVVILTQTSPEDITL..NKQATAVCLIS SFRP..DKLR  VDWLKDWQIITS..GVVTSLSVKEDN......GTFSTSSRLTVPARDW..RNDAVYTCQVTHV....PTQTIIVKNITKSS

CH3
AF003846,IGHM1*01   (D)CEDPTGNVKIYFLPLSPKQVLM..ESSVTLTCVVD NAPL...DVN  VSWTQGEKQL....SGYGKPSVTER.........HEVMSELNVSTEDW..KSGKEFFCVASHED..MPTPVREKIFQRT
AF003864,IGHM2*01    (E)CVDHGDVKVSFLPPSQKQVLM..ESSVILTCIVT NSPL...DVN  VDWTQGQTTL....QSGHGKQSATE........PQEVISELNISTHDW..ISGKEFNCIASHED..MPTPIREKIVKRE
AF003839,IGHM3*01c     (E)CLGEVKVSFLPPSPKQVLL..GDTVTLTCVVT EAPS...GVN  VTWTQGHMAR....QSARESRSA...........QRVTSELNVSTREW..NGGKEFECVANHVD..MLTPKRGTISKKP
AF004359,IGHM4*01c   (E)CVDHGDVKVSFLPPSQKQVLM..ESSVILTCIVT NSPL...DVN  VDWTQGQTTL....QSGHGKQSATE........PQEVISELNISTHDW..ISGKEFNCIASHED..MPTPIREKIVKRE
AF004360,IGHM5*01c   (E)CVDHGDVKVSFLPPSQKQVLM..ESSVILTCIVT NSPL...DVN  VDWTQGQTTL....QSGHGKQSATE........PQEVISELNISTHDW..ISGKEFNCIVSHED..MPTPIREKIVKRE

CH4
AF003847,IGHM1*01     (V)DHTKQPSVYILLPSAAELTA..QQSVTLTCLVK DFAP..KEIF  VQWTVDDKEIDVS.NYKNTELMADSAD.....RNYSMYSMLTISAGEW..GRGFSYSCIVGHET.FALKTLTRTVNKSSGKPSFVNISLVLMDAVNACQ*  
AF003865,IGHM2*01     (V)LHMKQPSVYLLLPSAEELST..HQSVTLTCLVK DFTP..KEIF  VEWAVNDQVIDAS.NYMNTEVMAASAD.....HNYSMYSMLTISAEDW..DRGHTYSCVVGHES.FPLKTLTRAVNKCSGKPSFVNISLVQMDTVNACQ*
AF003839,IGHM3*01c    (D)QDTNRPSVYLLLPSPEELSA..HQWVTLTCLVK EFAP..KEIF  VEWAVNDQAIDAS.QYTNTEAMAANTS.....HNYSMYSMLSVSAGDW..DKGNTYSCVVGHRS.FNSSKTLTRYVNKTSGKPTFVNVSLVLVDTVKTCQ*
AF004359,IGHM4*01c    (V)LHMKQPSVYLLLPSAEELST..HQSVTLTCLVK DFTP..KEIF  VEWAVNDQVIDAS.NYMNTEVMAASAD.....HNYSMYSMLTISAEDW..DRGHTYSCVVGHES.FPLKTLTRAVNKCSGKPSFVNISLVQMDTS
AF004360,IGHM5*01c    (V)LHMKQPSVYLLLPSAEELST..HQSVTLTCLVK DFTP..KEIF  VEWAVNDQVIDAS.NYMNTEVMAASAD.....HNYSMYSMLTISAEDW..DRGHTYSCVVGHES.FPLKTLTRAVNKC
AF003852,IGHM6*01        LHMKQPSVYLLLPSAEELST..HQSVTLTCLVK DFTP..KEIF  VEWAVNDQVIDAS.NYMNTEVMAASAD.....HNYSMYSMLTISAEDW..DRGHTYSCVVGHES.FPLKTLTRAVNKCSGKPSFVNISLVQMDTVNA

                                                M1
AF004360,IGHM5*01c       (S)DFPTEMMLEGFPPDESGNLWPTASTFIILFF
                         CONNECTING_REGION    | TRANSMEMBRANE-REGION       
         
c: cDNA sequence

Created: 02/10/2025 13:10
Author: Dominique Scaviner