Protein display: Human TRB V-REGIONs

Print of this table: Folch, G. et al., Exp. Clin. Immunogenet., 17, 205-215 (2000). PMID:11096259

Click here to see Part 2 - Orphons on chromosome 9 (9p21)


Only the *01 allele of each functional, ORF and in-frame pseudogene V-REGION is shown.

Letters in red correspond to amino acids which are polymorphic in the other alleles.
For C-REGIONs, letters in bold correspond to additional positions in the IMGT unique numbering.
For C-REGIONs, letters between parentheses correspond to amino acids resulting from the splicing.

N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CHS and in pages edited before 14/10/2009).

Part 1 - Sequences assigned to germline TRBV genes by sequence comparison

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      TRBV                          FR1-IMGT           CDR1-IMGT       FR2-IMGT      CDR2-IMGT                 FR3-IMGT                  CDR3-IMGT
      gene                           (1-26)             (27-38)        (39-55)        (56-65)                  (66-104)                  (105-115)
__________________________ __________________________ ____________ _________________ __________ _______________________________________ ___________
                           1       10        20         30         40        50         60         70        80        90        100        110
                           .........|.........|...... ...|........ .|.........|..... ....|..... ....|.........|.........|.........|.... .....|.....

  L36092 ,TRBV2(1)         EPEVTQTPSHQVTQMGQEVILRCVPI SNHLY....... FYWYRQILGQKVEFLVS FYNNEI.... SEKSEIFDDQFSVERP.DGSNFTLKIRSTKLEDSAMYFC ASSE.......
  U07977 ,TRBV3-1          DTAVSQTPKYLVTQMGNDKSIKCEQN LGHDT....... MYWYKQDSKKFLKIMFS YNNKEL.... IINETVP.NRFSPKSP.DKAHLNLHINSLELGDSAVYFC ASSQ.......
  U07977 ,TRBV4-1          DTEVTQTPKHLVMGMTNKKSLKCEQH MGHRA....... MYWYKQKAKKPPELMFV YSYEKL.... SINESVP.SRFSPECP.NSSLLNLHLHALQPEDSALYLC ASSQ.......
  U07975 ,TRBV4-2          ETGVTQTPRHLVMGMTNKKSLKCEQH LGHNA....... MYWYKQSAKKPLELMFV YNFKEQ.... TENNSVP.SRFSPECP.NSSHLFLHLHTLQPEDSALYLC ASSQ.......
  U07978 ,TRBV4-3          ETGVTQTPRHLVMGMTNKKSLKCEQH LGHNA....... MYWYKQSAKKPLELMFV YSLEER.... VENNSVP.SRFSPECP.NSSHLFLHLHTLQPEDSALYLC ASSQ.......
  L36092 ,TRBV5-1(1)       KAGVTQTPRYLIKTRGQQVTLSCSPI SGHRS....... VSWYQQTPGQGLQFLFE YFSETQ.... RNKGNFP.GRFSGRQF.SNSRSEMNVSTLELGDSALYLC ASSL.......
  X61439 ,TRBV5-3          EAGVTQSPTHLIKTRGQQVTLRCSPI SGHSS....... VSWYQQAPGQGPQFIFE YANELR.... RSEGNFP.NRFSGRQF.HDCCSEMNVSALELGDSALYLC ARSL.......
  L36092 ,TRBV5-4(1)       ETGVTQSPTHLIKTRGQQVTLRCSSQ SGHNT....... VSWYQQALGQGPQFIFQ YYREEE.... NGRGNFP.PRFSGLQF.PNYSSELNVNALELDDSALYLC ASSL.......
  L36092 ,TRBV5-5(1)       DAGVTQSPTHLIKTRGQQVTLRCSPI SGHKS....... VSWYQQVLGQGPQFIFQ YYEKEE.... RGRGNFP.DRFSARQF.PNYSSELNVNALLLGDSALYLC ASSL.......
  L36092 ,TRBV5-6(1)       DAGVTQSPTHLIKTRGQQVTLRCSPK SGHDT....... VSWYQQALGQGPQFIFQ YYEEEE.... RQRGNFP.DRFSGHQF.PNYSSELNVNALLLGDSALYLC ASSL.......
  L36092 ,TRBV5-7(1)       DAGVTQSPTHLIKTRGQHVTLRCSPI SGHTS....... VSSYQQALGQGPQFIFQ YYEKEE.... RGRGNFP.DQFSGHQF.PNYSSELNVNALLLGDSALYLC ASSL.......
  L36092 ,TRBV5-8(1)       EAGVTQSPTHLIKTRGQQATLRCSPI SGHTS....... VYWYQQALGLGLQFLLW YDEGEE.... RNRGNFP.PRFSGRQF.PNYSSELNVNALELEDSALYLC ASSL.......
  X61446 ,TRBV6-1          NAGVTQTPKFQVLKTGQSMTLQCAQD MNHNS....... MYWYRQDPGMGLRLIYY SASEGT.... TDKGEVP.NGYNVSRL.NKREFSLRLESAAPSQTSVYFC ASSE.......
  X61445 ,TRBV6-2          NAGVTQTPKFRVLKTGQSMTLLCAQD MNHEY....... MYWYRQDPGMGLRLIHY SVGEGT.... TAKGEVP.DGYNVSRL.KKQNFLLGLESAAPSQTSVYFC ASSY.......
  U07978 ,TRBV6-3          NAGVTQTPKFRVLKTGQSMTLLCAQD MNHEY....... MYWYRQDPGMGLRLIHY SVGEGT.... TAKGEVP.DGYNVSRL.KKQNFLLGLESAAPSQTSVYFC ASSY.......
  X61653 ,TRBV6-4          IAGITQAPTSQILAAGRRMTLRCTQD MRHNA....... MYWYRQDLGLGLRLIHY SNTAGT.... TGKGEVP.DGYSVSRA.NTDDFPLTLASAVPSQTSVYFC ASSD.......
  L36092 ,TRBV6-5(1)       NAGVTQTPKFQVLKTGQSMTLQCAQD MNHEY....... MSWYRQDPGMGLRLIHY SVGAGI.... TDQGEVP.NGYNVSRS.TTEDFPLRLLSAAPSQTSVYFC ASSY.......
  L36092 ,TRBV6-6(1)       NAGVTQTPKFRILKIGQSMTLQCTQD MNHNY....... MYWYRQDPGMGLKLIYY SVGAGI.... TDKGEVP.NGYNVSRS.TTEDFPLRLELAAPSQTSVYFC ASSY.......
  L36092 ,TRBV6-7(1)       NAGVTQTPKFHVLKTGQSMTLLCAQD MNHEY....... MYRYRQDPGKGLRLIYY SVAAAL.... TDKGEVP.NGYNVSRS.NTEDFPLKLESAAPSQTSVYFC ASSY.......
  L36092 ,TRBV6-8(1)       NAGVTQTPKFHILKTGQSMTLQCAQD MNHGY....... MSWYRQDPGMGLRLIYY SAAAGT.... TDK.EVP.NGYNVSRL.NTEDFPLRLVSAAPSQTSVYLC ASSY.......
  X61447 ,TRBV6-9          NAGVTQTPKFHILKTGQSMTLQCAQD MNHGY....... LSWYRQDPGMGLRRIHY SVAAGI.... TDKGEVP.DGYNVSRS.NTEDFPLRLESAAPSQTSVYFC ASSY.......
  X61444 ,TRBV7-1          GAGVSQSLRHKVAKKGKDVALRYDPI SGHNA....... LYWYRQSLGQGLEFPIY FQGKDA.... ADKSGLPRDRFSAQRS.EGSISTLKFQRTQQGDLAVYLC ASSS.......
  X61442 ,TRBV7-2          GAGVSQSPSNKVTEKGKDVELRCDPI SGHTA....... LYWYRQSLGQGLEFLIY FQGNSA.... PDKSGLPSDRFSAERT.GGSVSTLTIQRTQQEDSAVYLC ASSL.......
  X61440 ,TRBV7-3          GAGVSQTPSNKVTEKGKYVELRCDPI SGHTA....... LYWYRQSLGQGPEFLIY FQGTGA.... ADDSGLPNDRFFAVRP.EGSVSTLKIQRTERGDSAVYLC ASSL.......
  L36092 ,TRBV7-4(1)       GAGVSQSPRYKVAKRGRDVALRCDSI SGHVT....... LYWYRQTLGQGSEVLTY SQSDAQ.... RDKSGRPSGRFSAERP.ERSVSTLKIQRTEQGDSAVYLC ASSL.......
  L36092 ,TRBV7-6(1)       GAGVSQSPRYKVTKRGQDVALRCDPI SGHVS....... LYWYRQALGQGPEFLTY FNYEAQ.... QDKSGLPNDRFSAERP.EGSISTLTIQRTEQRDSAMYRC ASSL.......
  L36092 ,TRBV7-7(1)       GAGVSQSPRYKVTKRGQDVTLRCDPI SSHAT....... LYWYQQALGQGPEFLTY FNYEAQ.... PDKSGLPSDRFSAERP.EGSISTLTIQRTEQRDSAMYRC ASSL.......
  M11953 ,TRBV7-8          GAGVSQSPRYKVAKRGQDVALRCDPI SGHVS....... LFWYQQALGQGPEFLTY FQNEAQ.... LDKSGLPSDRFFAERP.EGSVSTLKIQRTQQEDSAVYLC ASSL.......
  L36092 ,TRBV7-9(1)       DTGVSQNPRHKITKRGQNVTFRCDPI SEHNR....... LYWYRQTLGQGPEFLTY FQNEAQ.... LEKSRLLSDRFSAERP.KGSFSTLEIQRTEQGDSAMYLC ASSL.......
  L36092 ,TRBV9(1)         DSGVTQTPKHLITATGQRVTLRCSPR SGDLS....... VYWYQQSLDQGLQFLIQ YYNGEE.... RAKGNIL.ERFSAQQF.PDLHSELNLSSLELGDSALYFC ASSV.......
  U17050 ,TRBV10-1         DAEITQSPRHKITETGRQVTLACHQT WNHNN....... MFWYRQDLGHGLRLIHY SYGVQD.... TNKGEVS.DGYSVSRS.NTEDLPLTLESAASSQTSVYFC ASSE.......
  U17049 ,TRBV10-2         DAGITQSPRYKITETGRQVTLMCHQT WSHSY....... MFWYRQDLGHGLRLIYY SAAADI.... TDKGEVP.DGYVVSRS.KTENFPLTLESATRSQTSVYFC ASSE.......
  U03115 ,TRBV10-3         DAGITQSPRHKVTETGTPVTLRCHQT ENHRY....... MYWYRQDPGHGLRLIHY SYGVKD.... TDKGEVS.DGYSVSRS.KTEDFLLTLESATSSQTSVYFC AISE.......
  M33233 ,TRBV11-1         EAEVAQSPRYKITEKSQAVAFWCDPI SGHAT....... LYWYRQILGQGPELLVQ FQDESV.... VDDSQLPKDRFSAERL.KGVDSTLKIQPAELGDSAMYLC ASSL.......
  L36092 ,TRBV11-2(1)      EAGVAQSPRYKIIEKRQSVAFWCNPI SGHAT....... LYWYQQILGQGPKLLIQ FQNNGV.... VDDSQLPKDRFSAERL.KGVDSTLKIQPAKLEDSAVYLC ASSL.......
  U03115 ,TRBV11-3         EAGVVQSPRYKIIEKKQPVAFWCNPI SGHNT....... LYWYLQNLGQGPELLIR YENEEA.... VDDSQLPKDRFSAERL.KGVDSTLKIQPAELGDSAVYLC ASSL.......
  X07192 ,TRBV12-3         DAGVIQSPRHEVTEMGQEVTLRCKPI SGHNS....... LFWYRQTMMRGLELLIY FNNNVP.... IDDSGMPEDRFSAKMP.NASFSTLKIQPSEPRDSAVYFC ASSL.......
  K02546 ,TRBV12-4         DAGVIQSPRHEVTEMGQEVTLRCKPI SGHDY....... LFWYRQTMMRGLELLIY FNNNVP.... IDDSGMPEDRFSAKMP.NASFSTLKIQPSEPRDSAVYFC ASSL.......
  X07223 ,TRBV12-5         DARVTQTPRHKVTEMGQEVTMRCQPI LGHNT....... VFWYRQTMMQGLELLAY FRNRAP.... LDDSGMPKDRFSAEMP.DATLATLKIQPSEPRDSAVYFC ASGL.......
  U03115 ,TRBV13           AAGVIQSPRHLIKEKRETATLKCYPI PRHDT....... VYWYQQGPGQDPQFLIS FYEKMQ.... SDKGSIP.DRFSAQQF.SDYHSELNMSSLELGDSALYFC ASSL.......
  X06154 ,TRBV14           EAGVTQFPSHSVIEKGQTVTLRCDPI SGHDN....... LYWYRRVMGKEIKFLLH FVKESK.... QDESGMPNNRFLAERT.GGTYSTLKVQPAELEDSGVYFC ASSQ.......
  U03115 ,TRBV15           DAMVIQNPRYQVTQFGKPVTLSCSQT LNHNV....... MYWYQQKSSQAPKLLFH YYDKDF.... NNEADTP.DNFQSRRP.NTSFCFLDIRSPGLGDTAMYLC ATSR.......
  L26231 ,TRBV16           GEEVAQTPKHLVRGEGQKAKLYCAPI KGHSY....... VFWYQQVLKNEFKFLIS FQNENV.... FDETGMPKERFSAKCL.PNSPCSLEIQATKLEDSAVYFC ASSQ.......
  U03115 ,TRBV17           EPGVSQTPRHKVTNMGQEVILRCDPS SGHMF....... VHWYRQNLRQEMKLLIS FQYQNI.... AVDSGMPKERFTAERP.NGTSSTLKIHPAEPRDSAVYLY SSG........
  L36092 ,TRBV18(1)        NAGVMQNPRHLVRRRGQEARLRCSPM KGHSH....... VYWYRQLPEEGLKFMVY LQKENI.... IDESGMPKERFSAEFP.KEGPSILRIQQVVRGDSAAYFC ASSP.......
  L36092 ,TRBV19           DGGITQSPKYLFRKEGQNVTLSCEQN LNHDA....... MYWYRQDPGQGLRLIYY SQIVND.... FQKGDIA.EGYSVSRE.KKESFPLTVTSAQKNPTAFYLC ASSI.......
  M11955 ,TRBV20-1         GAVVSQHPSWVICKSGTSVKIECRSL DFQATT...... MFWYRQFPKQSLMLMAT SNEGSKA... TYEQGVEKDKFLINHA.SLTLSTLTVTSAHPEDSSFYIC SAR........
  L36092 ,TRBV23-1(1)      HAKVTQTPGHLVKGKGQKTKMDCTPE KGHTF....... VYWYQQNQNKEFMLLIS FQNEQV.... LQETEMHKKRFSSQCP.KNAPCSLAILSSEPGDTALYLC ASSQ.......
  M11951 ,TRBV24-1         DADVTQTPRNRITKTGKRIMLECSQT KGHDR....... MYWYRQDPGLGLRLIYY SFDVKD.... INKGEIS.DGYSVSRQ.AQAKFSLSLESAIPNQTALYFC ATSDL......
  L36092 ,TRBV25-1(1)      EADIYQTPRYLVIGTGKKITLECSQT MGHDK....... MYWYQQDPGMELHLIHY SYGVNS.... TEKGDLS.SESTVSRI.RTEHFPLTLESARPSHTSQYLC ASSE.......
  L36092 ,TRBV27(1)        EAQVTQNPRYLITVTGKKLTVTCSQN MNHEY....... MSWYRQDPGLGLRQIYY SMNVEV.... TDKGDVP.EGYKVSRK.EKRNFPLILESPSPNQTSLYFC ASSL.......
  U08314 ,TRBV28           DVKVTQSSRYLVKRTGEKVFLECVQD MDHEN....... MFWYRQDPGLGLRLIYF SYDVKM.... KEKGDIP.EGYSVSRE.KKERFSLILESASTNQTSMYLC ASSL.......
  L36092 ,TRBV29-1(1)      SAVISQKPSRDICQRGTSLTIQCQVD SQVTM....... MFWYRQQPGQSLTLIAT ANQGSEA... TYESGFVIDKFPISRP.NLTFSTLTVSNMSPEDSSIYLC SVE........
  L36092 ,TRBV30(1)        SQTIHQWPATLVQPVGSPLSLECTVE GTSNPN...... LYWYRQAAGRGLQLLFY SVGIG..... QISSEVP.QNLSASRP.QDRQFILSSKKLLLSDSGFYLC AWS........
IMGT note:
(1) The original L36092 sequence (684973 bp) has been split in EMBL into three sequences of 267156 bp (U66059), 215422 bp (U66060) and 232650 bp (U66061), L36092 has become secondary accession number of U66059, U66060 and U66061.
In IMGT, the original sequence L36092 which is fully annotated has also been kept as primary accession number, in addition to U66059, U66060 and U66061.

Created: 28/11/1997
Last updated: Wednesday, 12-Jun-2024 16:02:40 CEST
Author: Géraldine Folch