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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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IMGT subgroup IMGT gene name IMGT allele name Fct R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Accession numbers Positions in the sequence (V-REGION) Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence (V-REGION)
TRBV1 TRBV1S1 TRBV1S1*01 (F) + + VB1 U18123 [1] #c 61-354
TRBV1S2 TRBV1S2*01 (F) + + AJ517910 [2] #c 61-354
TRBV1S3 TRBV1S3*01 (F) + + AJ517915 [2] #c 61-354
TRBV1S4 TRBV1S4*01 (F) + + AJ517915 [2] #c 61-354
TRBV1S5 TRBV1S5*01 (F) + + AJ517915 [2] #c 22-315
TRBV2 TRBV2S1 TRBV2S1*01 (F) + + VB2 U18124 [1] #c 64-342
TRBV2S2 TRBV2S2*01 [P] AF329703 [3] (1) ° 201-481
TRBV2S3 TRBV2S3*01 [F] AF329705 [3] ° 208-489 AF329701 [3] °
TRBV2S4 TRBV2S4*01 [F] AF329708 [3] ° 166-447
TRBV2S5 TRBV2S5*01 [F] AF329713 [3] ° 315-595
TRBV2S6 TRBV2S6*01 [F] AF329704 [3] ° 203-482
TRBV2S7 TRBV2S7*01 [F] AF329718 [3] ° 235-515
TRBV2S8 TRBV2S8*01 [F] AF329714 [3] ° 235-515
TRBV2S9 TRBV2S9*01 [F] AF329710 [3] (2) ° 234-514
TRBV2S10 TRBV2S10*01 [F] AF329719 [3] ° 200-480
TRBV2S11 TRBV2S11*01 [P] AF329723 [3] (3) ° 332-612
TRBV2S12 TRBV2S12*01 (F) + + AF329722 [3] #c 64-344
TRBV2S13 TRBV2S13*01 (F) + + AF329700 [3] #c 138-413
TRBV2S14 TRBV2S14*01 [F] AF329706 [3] ° 312-588
TRBV2S15 TRBV2S15*01 (P) + + AF329716 [3] (1) #c 1-281
TRBV2S16 TRBV2S16*01 [F] AF329717 [3] ° 315-595 AF329715 [3] °
TRBV2S17 TRBV2S17*01 [F] AF329702 [3] ° 182-462
TRBV2S18 TRBV2S18*01 [F] AF329725 [3] ° 172-452
TRBV2S19 TRBV2S19*01 [F] AF329707 [3] ° 156-436
TRBV2S20 TRBV2S20*01 [F] AF329706 [3] ° 170-450
TRBV2S21 TRBV2S21*01 [P] AF329724 [3] (4) ° 160-440
TRBV2S22 TRBV2S22*01 [P] AF329706 [3] (5) ° 166-445
TRBV2S23 TRBV2S23*01 [F] AF329726 [3] ° 182-463
TRBV2S24 TRBV2S24*01 [F] AF329711 [3] ° 204-484
TRBV2S25 TRBV2S25*01 [ORF] AF329712 [3] (6) ° 357-637
TRBV2S26 TRBV2S26*01 [P] AF329721 [3] (4) ° 393-673
TRBV2S27 TRBV2S27*01 (F) + + AJ517925 [2] #c 64-342
TRBV3 TRBV3S1 TRBV3S1*01 (F) + + VB3 U18125 [1] #c 61-357
TRBV3S2 TRBV3S2*01 (F) + + AJ517930 [2] #c 1-273
TRBV4 TRBV4S1 TRBV4S1*01 (F) + + VB4 AY135385 [2] #c 61-351
TRBV5 TRBV5S1 TRBV5S1*01 (F) + + VB5 AY135386 [2] #c 67-369
TRBV6 TRBV6S1 TRBV6S1*01 (F) + + VB6 AY135387 [2] #c 79-354 VB6 variant AY135388 [2] (7) #c
TRBV7 TRBV7S1 TRBV7S1*01 (F) + + VB7 AY135389 [2] #c 70-360
TRBV7S2 TRBV7S2*01 (F) + + AJ517966 [2] #c 70-360
TRBV7S3 TRBV7S3*01 (F) + + AJ517967 [2] #c 55-345
TRBV7S4 TRBV7S4*01 (F) + + AJ517968 [2] #c 7-297
TRBV8 TRBV8S1 TRBV8S1*01 (F) + + VB8 AY135390 [2] (8) #c 58-342
TRBV8S2 TRBV8S2*01 (F) + + AJ517978 [2] #c 58-342
TRBV8S3 TRBV8S3*01 (F) + + AJ517980 [2] #c 1-273
TRBV9 TRBV9S1 TRBV9S1*01 (F) + + VB9 AY135391 [2] #c 61-336
TRBV10 TRBV10S1 TRBV10S1*01 (F) + + VB10 AY135392 [2] #c 94-378

#c: rearranged cDNA.
° : DNA genomic sequence, but not known as being germline or rearranged.

IMGT notes:
  1. (1) Pseudogene because of frameshift in L-PART1.
  2. (2) Functional but the DONOR-SPLICE is ngn instead of ngt
  3. (3) Pseudogene because of frameshift in L-PART1 and STOP-CODON in FR2-IMGT.
  4. (4) Pseudogene because of STOP-CODON in FR1-IMGT.
  5. (5) Pseudogene because of frameshift in FR3-IMGT.
  6. (6) ORF because of non canonical DONOR-SPLICE: ngg instead of ngt
  7. (7) Truncated V-REGION
  8. (8) Functional but cDNA sequence is unproductive due to a STOP-CODON in JUNCTION
IMGT references:
  1. [1] Partula S. et al., J. Immunol., 155, 699-706 (1995). PMID:7608547
  2. [2] Boudinot P. et al., J.Immunol., 169, 6244-6252 (2002). PMID:12444130
  3. [3] Zhang H. et al., Unpublished.
Created:
25/10/2009
Last updated:
22/09/2023
Authors:
Géraldine Folch & Amandine Lacan