IMGT Repertoire (RPI)

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Other B7 Family entries

Homo sapiens: B7A1, B7A2, B7H1, B7DC, B7H2, B7H3, B7H4
Mus musculus: B7A1, B7A2, B7H1, B7DC, B7H3, B7H4

IMGT RPI entry from gene to protein for Mus musculus B7H2

Citing IMGT RPI entry for B7H2

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004)

with permission from Research Signpost

IMGT gene name and definition

IMGT gene name: Mus musculus B7H2
IMGT gene definition: inducible T-cell co-stimulator ligand

Chromosomal localization

Chromosome: 10
Chromosomal localization: 10 C1

Gene exon/intron organization

Legend:

Length of the exons and introns are in base pairs.
Colors are according to IMGT Color menu for regions and domains

Number of alleles: 2

IMGT reference alleles

Allele names	Gene functionality	IMGT reference sequences
Allele names	Gene functionality	Exons	Accession numbers	Molecule type
B7H2*01	F	EX1-7	AF394451[1]	cDNA
B7H2*02	F	EX1-6, 8	AF199027 [2]	cDNA (1) splicing B

IMGT reference sequences (in FASTA format) for the allele(s): B7H2*01 to B7H2*02

Nucleotide sequence in FASTA format with gaps according to the IMGT unique numbering
Amino acid sequence in FASTA format with gaps according to the IMGT unique numbering
Nucleotide sequence in FASTA format without gaps
Amino acid sequence in FASTA format without gaps

Other sequences from the literature

Allele names	Gene functionality	IMGT reference sequences
Allele names	Gene functionality	Exons	Accession numbers	Molecule type
B7H2*02	F	EX1-6,8	AF216747	cDNA splicing B
			BC029227	cDNA splicing B
			AK041421	cDNA splicing B
			AK136074	cDNA splicing B
			NM_015790	cDNA splicing B

Corresponding protein database accession numbers

Allele names	Accession numbers		Number of amino acids	Protein isoform
Allele names	Nucleotide databases	Protein databases	Number of amino acids	Protein isoform
B7H2*01	AF394451		347 aa	1
B7H2*01	NM_015790	NP_056605	322 aa	2

IMGT notes:

(1) Splicing B (322 aa). No EX7. In EX4 a48>g, a295>g; H99>R, positions according to the IMGT unique numbering for the C-DOMAIN and C-LIKE-DOMAIN.

IMGT references:

[1] Ling V. et al. The Journal of Immunology, 166, 7300-7308(2001). PMID:11390480
[2] Ling V. et al. The Journal of Immunology, 164, 1653-1657(2000). PMID:10657606

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

B7H2*01: AF199028(c)

Nucleotide sequence

1        atgcagctaa agtgtccctg ttttgtgtcc ttgggaacca ggcagcctgt ttggaagaag

61       ctccatgttt ctagcgggtt cttttctggt cttggtctgt tcttgctgct gttgagcagc

121      ctctgtgctg cctctgcaga gactgaagtc ggtgcaatgg tgggcagcaa tgtggtgctc

181      agctgcattg acccccacag acgccatttc aacttgagtg gtctgtatgt ctattggcaa

241      atcgaaaacc cagaagtttc ggtgacttac tacctgcctt acaagtctcc agggatcaat

301      gtggacagtt cctacaagaa caggggccat ctgtccctgg actccatgaa gcagggtaac

361      ttctctctgt acctgaagaa tgtcacccct caggataccc aggagttcac atgccgggta

421      tttatgaata cagccacaga gttagtcaag atcttggaag aggtggtcag gctgcgtgtg

481      gcagcaaact tcagtacacc tgtcatcagc acctctgata gctccaaccc aggccaggaa

541      cgtacctaca cctgcatgtc caagaatggc tacccagagc ccaacctgta ttggatcaac

601      acaacggaca atagcctaat agacacggct ctgcagaata acactgtcta cttgaacaag

661      ttgggcctgt atgatgtaat cagcacatta aggctccctt ggacatctca tggggatgtt

721      ctgtgctgcg tagagaatgt ggctctccac cagaacatca ctagcattag ccaggcagaa

781      agtttcactg gaaataacac aaagaaccca caggaaaccc acaataatga gttaaaagtc

841      cttgtccccg tccttgctgt actggcggca gcggcattcg tttccttcat catatacaga

901      cgcacgcgtc cccaccgaag ctatacagga cccaagactg tacagcttga acttacagac

961      acttgggctc cggtccccta ccaggactat ttgattccaa gatatttgat gtctccatgc

1021     ctcaaaacac gtggtttacc ataa

Nucleotide sequence in FASTA format (without gaps) B7H2*01

Amino acid sequence

1        MQLKCPCFVS LGTRQPVWKK LHVSSGFFSG LGLFLLLLSS LCAASAETEV GAMVGSNVVL

61       SCIDPHRRHF NLSGLYVYWQ IENPEVSVTY YLPYKSPGIN VDSSYKNRGH LSLDSMKQGN

121      FSLYLKNVTP QDTQEFTCRV FMNTATELVK ILEEVVRLRV AANFSTPVIS TSDSSNPGQE

181      RTYTCMSKNG YPEPNLYWIN TTDNSLIDTA LQNNTVYLNK LGLYDVISTL RLPWTSHGDV

241      LCCVENVALH QNITSISQAE SFTGNNTKNP QETHNNELKV LVPVLAVLAA AAFVSFIIYR

301      RTRPHRSYTG PKTVQLELTD TWAPVPYQDY LIPRYLMSPC LKTRGLP*

Amino acid sequence in FASTA format (without gap) B7H2*01

Legend:

Colors are according to IMGT Color menu for regions and domains
Nucleotide and amino acid letters (in bold) in purple, green or blue are according to IMGT Color menu for splicing types.

IMGT links

IMGT Repertoire

Chromosomal localization:
Alignment of alleles:
Protein displays:
IMGT Collier de perles: V-LIKE-DOMAIN on one layer, V-LIKE-DOMAIN on two layers, C-LIKE-DOMAIN on one layer, C-LIKE-DOMAIN on two layers

External links

Nomenclature

HGNC:

Genome databases

Entrez Gene: 50723
MGI: 1354701
GENATLAS:
GeneCards:
GDB:
OMIM:

Sequence database

EMBL: AF394451, AX100593, AX100591, AF216747, BC029227, AF199027, AK136074, AK041421, AC041421
GenBank: AF394451, AX100593, AX100591, AF216747, BC029227, AF199027, AK136074, AK041421, AC041421
DDBJ: AF394451, AX100593, AX100591, AF216747, BC029227, AF199027, AK136074, AK041421, AC041421
Swiss-Prot:
TrEMBL: Q3UWV7, Q544C7, Q571G9, Q9JHJ8
NCBI: NM_015790, NP_056605

Structure database

PDB: