IMGT Web resources: IMGT repertoire

Table of alleles: Human IGHC

Functionality is shown between parentheses, (F) and (P), when the accession number refers to a cDNA sequence and the corresponding genomic gene has not yet been isolated.

Click on a gene name to get the alignment of the corresponding C-REGION alleles.
Click on an accession number to get the sequence and additional information (IMGT annotations, IMGT flat file, Coding regions...).

IMGT note:

(1) Not submitted but comment in J00222.

Reference:
[1] Max, E.E. et al., Cell, 29, 691-699 (1982).

Created: 29/04/2003
Author: Nathalie Bosc

IGHC gene name	Exons	Fct	IGHC allele name	Accession numbers	Confirmed by genetics and or data	Description of mutations
IGHA1	CH1	F	IGHA1*01	J00220	+
	H	F	IGHA1*01	J00220	+
	CH2	F	IGHA1*01	J00220	+
	CH3 (including CHS)	F	IGHA1*01	J00220
	M	F	IGHA1*01	M60193
IGHA2	CH1	F	IGHA2*01	J00221		`c343 ,P115 \|c371 ,P124 \|`
			IGHA2*02	M60192		`c343>t,P115>S\|c371>g,P124>R\|`
			IGHA2*03	S71043		`c343>t,P115>S\|c371>g,P124>R\|`
	H	F	IGHA2*01	J00221
			IGHA2*02	M60192
			IGHA2*03	S71043
	CH2	F	IGHA2*01	J00221
			IGHA2*02	M60192,AJ012264
			IGHA2*03	S71043
	CH3 (including CHS)	F	IGHA2*01	J00221		`t254.2 ,F85.2 \|g255 \|c279 \|c300 ,D100 \|t370 ,L124 \|t399 \|g400 ,V134 \|t428 ,V143 \|c432 \|`
			IGHA2*02	AJ012264		`t254.2>a,F85.2>Y\|g255>a\|c279>t\|c300>g,D100>E\|t370>a,L124>M\|t399>c\|g400>a,V134>I\|t428>c,V143>A\|c432>t\|`
			IGHA2*03	S71043
	M	F	IGHA2*02	M60194
IGHD	CH1	F	IGHD*01	K02875
	CH1	F	IGHD*02	X57331
	H1	F	IGHD*01	K02876		`c27 \|`
	H1	F	IGHD*02	X57331		`c27>a\|`
	H2	F	IGHD*01	K02877
	H2	F	IGHD*02	X57331
	CH2	F	IGHD*01	K02878
	CH2	F	IGHD*02	X57331
	CH3	F	IGHD*01	K02879		`t18 \|`
	CH3	F	IGHD*02	X57331		`t18>c\|`
	CHS	F	IGHD*01	K02880
	CHS	F	IGHD*02	X57331
	M1	F	IGHD*01	K02881
	M1	F	IGHD*02	X57331
	M2	F	IGHD*01	K02882
	M2	F	IGHD*02	X57331
IGHE	CH1	F	IGHE*01	J00222		`c123 ,C41 \|`
			IGHE*02	L00222		`c123>g,C41>W\|`
			IGHE*03	[1](1)
	CH2	F	IGHE*01	J00222
			IGHE*02	V00555/L00222
			IGHE*03	[1](1)
	CH3	F	IGHE*01	J00222
			IGHE*02	V00555/L00222
			IGHE*03	[1](1)
	CH4 (including CHS)	F	IGHE*01	J00222		`g122 ,W41 \|`
			IGHE*02	V00555/L00222
			IGHE*03	[1](1)		`g122>t,W41>L\|`
	M1	F	IGHE*01	X63693
	M1	F	IGHE*03	M55420
	M2	F	IGHE*01	X63693
	M2	F	IGHE*03	M55420
IGHEP1	CH3	P	IGHEP1*01	J00223		`a1.3 ,c3.3 ,N1.3 \|a3.2 \|a1.1 ,g2.1 ,a3.1 ,R1.1 \|g1 ,G1 \|c9 ,S3 \|c11 ,A4 \|g265 ,V89 \|a294 \|a330 ,Q110 \|`
			IGHEP1*02	X84668		`a1.3>c,c3.3>a,N1.3>Q\|a3.2>c\|a1.1>g,g2.1>a,a3.1>g,R1.1>E\|g1>a,G1>R\| \|g265>c,V89>L\| \|a330>c,Q110>H\|`
			IGHEP1*03	X84669		`\|c9>g,S3>R\|c11>t,A4>V\|g265>c,V89>L\|a294>g\|a330>c,Q110>H\|`
	CH4 (including CHS)	P	IGHEP1*01	J00223
IGHG1	CH1	F	IGHG1*01	J00228		`a359 ,K120 \|`
		F	IGHG1*02	Z17370
		(F)	IGHG1*03	Y14737		`a359>g,K120>R\|`
	H	F	IGHG1*01	J00228
		F	IGHG1*02	Z17370
		(F)	IGHG1*03	Y14737
	CH2	F	IGHG1*01	J00228		`g255.1 \|`
		F	IGHG1*02	Z17370		`g255.1>t\|`
		(F)	IGHG1*03	Y14737		`g255.1>t\|`
	CH3 (including CHS)	F	IGHG1*01	J00228		`t36 ,D12 \|c40 ,L14 \|c258 \|t372 \|`
		F	IGHG1*02	Z17370
		(F)	IGHG1*03	Y14737		`t36>g,D12>E\|c40>a,L14>M\|c258>t\|t372>c\|`
	M1	(F)	IGHG1*01	X52847
	M2	(F)	IGHG1*01	X52847
IGHG2	CH1	F	IGHG2*01	J00230		`c57 \|a246 \|c274 ,P92 \|a284 ,N95 \|c288 ,F96 \|`
			IGHG2*02	AJ250170		`c57>g\|a246>g\|c274>a,P92>T\|`
			IGHG2*03	AF449616		`c57>g\|`
			IGHG2*04	AF449617		`c57>g\| \|a284>g,N95>S\|c288>g,F96>L\|`
			IGHG2*05	AF449618		`c57>g\|`
			IGHG2*06	AL928742		`c57>g\|a246>g\|`
	H	F	IGHG2*01	J00230	+
			IGHG2*02	AJ250170	+
			IGHG2*03	AF449616
			IGHG2*04	AF449617
			IGHG2*05	AF449618
			IGHG2*06	AL928742
	CH2	F	IGHG2*01	J00230	+	`g135.1 ,V45.1 \|t273 \|`
			IGHG2*02	AJ250170	+	`g135.1>a,V45.1>M\|t273>c\|`
			IGHG2*03	AF449616
			IGHG2*04	AF449617
			IGHG2*05	AF449618
			IGHG2*06	AL928742		`\|t273>c\|`
	CH3 (including CHS)	F	IGHG2*01	J00230	+	`g106 \|a243 \|g351 \|`
			IGHG2*02	AJ250170	+	`\|g351>a\|`
			IGHG2*03	AF449616
			IGHG2*04	AF449617
			IGHG2*05	AF449618		`\|a243>g\|`
			IGHG2*06	AL928742		`g106>t,A36>S\| \|g351>a\|`
	M1	F	IGHG2*01	AB00675		`g21 \|`
	M1	F	IGHG2*06	AL928742		`g21>c\|`
	M2	F	IGHG2*01	AB00676
	M2	F	IGHG2*06	AL928742
IGHG3	CH1	F	IGHG3*01	X03604	+	`t3.4 \|c90 \|c251.3 ,S84.3 \|g284 ,S95 \|g288 ,L96 \|`
			IGHG3*02	K01313
			IGHG3*03	X16110	+
			IGHG3*04	X99549		`t3.4>c\|`
			IGHG3*05	AJ390236
			IGHG3*06	AJ390237		`\|c90>a\|`
			IGHG3*07	AJ390238	+
			IGHG3*08	AJ390241
			IGHG3*09	AJ390242	+
			IGHG3*10	AJ390246		`\|c90>a\|`
			IGHG3*11	AJ390247	+
			IGHG3*12	AJ390252	+
			IGHG3*13	AJ390244	+
			IGHG3*14	AJ390254	+
			IGHG3*15	AJ390260	+
			IGHG3*16	AJ390262	+
			IGHG3*17	AJ390272	+	`\|g284>a,S95>N\|g288>c,L96>F\|`
			IGHG3*18	AJ390276	+	`\|c251.3>a,S84.3>Y\|`
			IGHG3*19	AJ390279	+
	H1	F	IGHG3*01	M12958	+
			IGHG3*02	K01313
			IGHG3*03	X16110	+
			IGHG3*04	X99549
			IGHG3*05	AJ390236
			IGHG3*06	AJ390237
			IGHG3*07	AJ390238	+
			IGHG3*08	AJ390241
			IGHG3*09	AJ390242	+
			IGHG3*10	AJ390246
			IGHG3*11	AJ390247	+
			IGHG3*12	AJ390252	+
			IGHG3*13	AJ390244	+
			IGHG3*14	AJ390254	+
			IGHG3*15	AJ390260	+
			IGHG3*16	AJ390262	+
			IGHG3*17	AJ390272	+
			IGHG3*18	AJ390276	+
			IGHG3*19	AJ390279	+
	H2	F	IGHG3*01	M12958	+	`c6 \|`
			IGHG3*02	K01313		`c6>t\|`
			IGHG3*03	X16110	+
			IGHG3*04	X99549
			IGHG3*05	AJ390236
			IGHG3*06	AJ390237
			IGHG3*07	AJ390238	+
			IGHG3*08	AJ390241
			IGHG3*09	AJ390242	+
			IGHG3*10	AJ390246
			IGHG3*11	AJ390247	+
			IGHG3*12	AJ390252	+
			IGHG3*13	AJ390244	+
			IGHG3*14	AJ390254	+
			IGHG3*15	AJ390260	+
			IGHG3*16	AJ390262	+
	H3	F	IGHG3*01	M12958	+	`c6 \|a30 \|`
			IGHG3*02	K01313		`c6>t\|a30>g\|`
			IGHG3*03	X16110	+
			IGHG3*04	X99549
			IGHG3*05	AJ390236
			IGHG3*06	AJ390237
			IGHG3*07	AJ390238	+
			IGHG3*08	AJ390241
			IGHG3*09	AJ390242	+
			IGHG3*10	AJ390246
IGHG3*11			AJ390247	+
IGHG3*12			AJ390252	+
IGHG3*13			AJ390244	+
IGHG3*14			AJ390254	+
IGHG3*15			AJ390260	+
IGHG3*16			AJ390262	+
IGHG3*17			AJ390272	+	`\|a30>g\|`
IGHG3*18			AJ390276	+	`\|a30>g\|`
IGHG3*19			AJ390279	+	`\|a30>g\|`
H4	F	IGHG3*01	M12958	+	`g30 \|a37 \|`
		IGHG3*02	K01313
		IGHG3*03	X16110	+
		IGHG3*04	X99549
		IGHG3*05	AJ390236
		IGHG3*06	AJ390237
		IGHG3*07	AJ390238	+
		IGHG3*08	AJ390241
		IGHG3*09	AJ390242	+
		IGHG3*10	AJ390246
		IGHG3*11	AJ390247	+	`g30>a\|a37>c\|`
		IGHG3*12	AJ390252	+	`g30>a\|a37>c\|`
		IGHG3*13	AJ390244	+
		IGHG3*14	AJ390254	+
		IGHG3*15	AJ390260	+
		IGHG3*16	AJ390262	+
		IGHG3*17	AJ390272	+
		IGHG3*18	AJ390276	+
		IGHG3*19	AJ390279	+
CH2	F	IGHG3*01	M12958	+	`a27 \|c245 ,P82 \|c247 ,R83 \|a251.3 ,Y84.3 \|c274 ,L92 \|a370 ,T124 \|`
		IGHG3*02	K01313		`a27>t\|`
		IGHG3*03	X16110	+
		IGHG3*04	X99549
		IGHG3*05	AJ390236
		IGHG3*06	AJ390237
		IGHG3*07	AJ390238	+
		IGHG3*08	AJ390241
		IGHG3*09	AJ390242	+	`\|c274>g,L92>V\|`
		IGHG3*10	AJ390246
		IGHG3*11	AJ390247	+	`\|a251.3>t,Y84.3>F\|`
		IGHG3*12	AJ390252	+	`\|a251.3>t,Y84.3>F\|`
		IGHG3*13	AJ390244	+
		IGHG3*14	AJ390254	+	`\|c245>t,P82>L\|`
		IGHG3*15	AJ390260	+	`\|c245>t,P82>L\|`
		IGHG3*16	AJ390262	+	`\|c245>t,P82>L\| \|a370>g,T124>A\|`
		IGHG3*17	AJ390272	+
		IGHG3*18	AJ390276	+	`\|c247>t,R83>W\|`
		IGHG3*19	AJ390279	+	`\|c247>t,R83>W\|`
CH3 (including CHS)	F	IGHG3*01	M12958	+	`a3.4 \|g115 ,V39 \|g131 ,c132 ,S44 \|c134.2 \|g133.3 ,g135.3 ,E45.3 \|c237 ,N79 \|g243 \|a250 ,M84 \|a263 ,K88 \|c267 \|c270 \|c292 ,Q98 \|c300 \|a301 ,I101 \|g344 ,R115 \|t347 ,F116 \|`
		IGHG3*02	K01314		`\|c134.2>a\|g133.3>a,g135.3>c,E45.3>N\|`
		IGHG3*03	X16110	+	`\|a250>g,M84>V\|a263>g,K88>R\|c267>a\| \|c292>g,Q98>E\|c300>t\|a301>g,I101>V\|`
		IGHG3*04	X99549
		IGHG3*05	AJ390236
		IGHG3*06	AJ390237		`a3.4>g\| \|c237>g,N79>K\|`
		IGHG3*07	AJ390238	+	`a3.4>g\| \|c237>g,N79>K\|`
		IGHG3*08	AJ390241		`\|g131>a,c132>t,S44>N\|`
		IGHG3*09	AJ390242	+	`\|c270>t\|`
		IGHG3*10	AJ390246
		IGHG3*11	AJ390247	+
		IGHG3*12	AJ390252	+
		IGHG3*13	AJ390244	+	`\|c237>g,N79>K\|g243>a\| \|c292>g,Q98>E\|`
		IGHG3*14	AJ390254	+	`\|g131>a,c132>t,S44>N\| \|t347>a,F116>Y\|`
		IGHG3*15	AJ390260	+	`\|g131>a,c132>t,S44>N\| \|c137>g,N79>K\| \|t347>a,F116>Y\|`
		IGHG3*16	AJ390262	+	`\|g131>a,c132>t,S44>N\| \|t347>a,F116>Y\|`
		IGHG3*17	AJ390272	+	`\|g115>a,V39>M\| \|c237>g,N79>K\| \|a250>g,M84>V\| \|g344>a,R115>H\|t347>a,F116>Y\|`
		IGHG3*18	AJ390276	+	`\|g115>a,V39>M\| \|c237>g,N79>K\| \|a250>g,M84>V\| \|g344>a,R115>H\|t347>a,F116>Y\|`
		IGHG3*19	AJ390279	+	`\|g115>a,V39>M\| \|c237>g,N79>K\| \|a250>g,M84>V\| \|g344>a,R115>H\|t347>a,F116>Y\|`
M1	F	IGHG3*01	D78345		`c78 ,F26 \|`
M1	F	IGHG3*03	M60195		`c78>g,F26>L\|`
M2	F	IGHG3*01	D78345
M2	F	IGHG3*03	M60196
IGHG4	CH1	F	IGHG4*01	K01316
	H	F	IGHG4*01	K01316		`a21 \|`
	H	F	IGHG4*02	AJ001563		`a21>g\|`
	CH2	F	IGHG4*01	K01316		`c274 ,L92 \|`
			IGHG4*02	AJ001563		`c274>g,L92>V\|`
			IGHG4*03	AJ001564
	CH3 (including CHS)	F	IGHG4*01	K01316		`g263 ,R88 \|a267 \|t300 \|a351 \|`
			IGHG4*02	AJ001563		`\|a351>g\|`
			IGHG4*03	AJ001564		`g263>a,R88>K\|a267>c\|t300>c\|a351>g\|`
IGHGP	CH1	ORF	IGHGP*01	X06766
	H	ORF	IGHGP*01	X06766
	CH2	ORF	IGHGP*01	X06766
	CH3 (including CHS)	ORF	IGHGP*01	X06766
	M1	ORF	IGHGP*01	X52849
	M2	ORF	IGHGP*01	X52848
IGHM	CH1	F	IGHM*01	X14940		`g117 ,L39 \|t231 \|`
			IGHM*02	K01307
			IGHM*03	X57331		`g117>c,L39>F\|t231>c\|`
	CH2	F	IGHM*01	X14940		`c3.3 \|g292 ,G98 \|`
			IGHM*02	K01308,K01309		`c3.3>t\|`
			IGHM*03	X57331		`c3.3>t\|g292>a,G98>S\|`
	CH3	F	IGHM*01	X14940		`c45.1 \|c294 \|`
			IGHM*02	K01309,V00561	+	`c45.1>g\|c294>g\|`
			IGHM*03	X57331
	CH4 (including CHS)	F	IGHM*01	X14940		`a279 \|316^318 ,105^107 \|g327 ,E109 \|`
			IGHM*02	J00260	+	`a279>g\| \|g327>c,E109>D\|`
			IGHM*03	X57331		`\|316^318>ins^gtg,105^107>ins^V\|`
	M1	F	IGHM*01	X14940
	M1	F	IGHM*03	X57331
	M2	F	IGHM*01	X14940
	M2	F	IGHM*03	X57331