IMGT Scientific chart
Correspondence between V numberings
- IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN
- Correspondence between the IMGT unique Lefranc numbering and the different Kabat numberings (vertical display of examples) 1997
- Correspondence between the IMGT unique Lefranc numbering and the different numberings (horizontal display) 1998
- IMGT unique numbering (Lefranc) and structural correspondence for the different CDR-IMGT lengths with the diverse Kabat/Chothia numberings and CDR/loop delimitations (horizontal display per locus) 2008
Correspondence between numberings for CDR of different lengths (horizontal display)
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CDR1-IMGT
This table displays the correspondence between the IMGT unique Lefranc numbering [1], Kabat [2] and Chothia [3-5] numberings for CDR1 of different lengths, with gaps indicated by dashes. For a table showing the same CDR1 amino acid numberings but without gaps, and therefore without correspondence, click here.
Asterisks indicate positions for which it is not possible to make changes from one numbering to the other, automatically [1].
Brackets indicate the limits of the CDR in each numbering.
Click on the protein name for the CDR1-IMGT 3D structure.
For more information on the proteins, see
Protein with known 3D structures
Identification and Colliers de Perles: Human Immunoglobulins
IMGT FR1-IMGT CDR1-IMGT FR2-IMGT unique C W numbering [1] 23 24 25 26 [27 28 29 30 31 32 33 34 35 36 37 38] 39 40 41 CDR CDR1- length[2] IMGT[1] * * * * * * * * * * IGHV [2] 22 23 24 25 26 27 28 29 30 [31 32 33 34 35 - - 35A 35B]36 7 10 and VH 22 23 24 25 26 27 28 29 30 [31 32 33 34 35 - - 35A - ]36 6 9 22 23 24 25 26 27 28 29 30 [31 32 33 34 35 - - - - ]36 5 8 H1"canonical H1 CDR1- Example structure" length[5] IMGT[1] of proteins * * * * * * * * IGHV [5] 22 23 24 25 [26 27 28 29 30 31 31a 31b 32] 33 - - 34 35 36 3 9 10 and VH [5] 22 23 24 25 [26 27 28 29 30 31 31a - 32] 33 - - 34 35 36 2 8 9 [3-5] 22 23 24 25 [26 27 28 29 30 31 - - 32] 33 - - 34 35 36 1 7 8 Kol, Newm, McPC603, J539 IMGT FR1-IMGT CDR1-IMGT FR2-IMGT unique C W numbering [1] 23 24 25 26 [27 28 29 30 31 32 33 34 35 36 37 38] 39 40 41 CDR CDR1- length[2] IMGT[1] * * * * * * * * * * * IGKV [2] 23 [24 25 26 27 27A 27B 27C 27D 27E 27F 28 29 30 31 32 33 34] 35 17 12 and V-KAPPA 23 [24 25 26 27 27A 27B 27C 27D 27E - 28 29 30 31 32 33 34] 35 16 11 23 [24 25 26 27 27A 27B 27C 27D - - 28 29 30 31 32 33 34] 35 15 10 23 [24 25 26 27 27A - - - - - 28 29 30 31 32 33 34] 35 12 7 23 [24 25 26 27 - - - - - - 28 29 30 31 32 33 34] 35 11 6 23 [24 25 26 27 - - - - - - - 29 30 31 32 33 34] 35 10 5 L1"canonical L1 CDR1- Example structure" length[5] IMGT[1] of proteins * * * * * * * * * IGKV [3,4] 23 24 25 [26 27 28 29 30 31 31a 31b 31c 31d 31e 31f 32] 33 34 35 3 13 12 McPC603 and V-KAPPA 23 24 25 [26 27 28 29 30 31 31a - 31c 31d 31e 31f 32] 33 34 35 4 12 11 4-4-20 23 24 25 [26 27 28 29 30 31 - - - - - - 32] 33 34 35 2 7 6 Rei 23 24 25 [26 27 28 29 30 - - - - - - - 32] 33 34 35 1 6 5 J539 * * * * * * * * * IGKV [5] 23 24 25 [26 27 28 29 30 30a 30b 30c 30d 30e 30f 31 32] 33 34 35 3 13 12 McPC603 and V-KAPPA 23 24 25 [26 27 28 29 30 30a 30b 30c - 30e 30f 31 32] 33 34 35 4 12 11 4-4-20 23 24 25 [26 27 28 29 30 30a 30b - - 30c 30d 31 32] 33 34 35 5 11 10 23 24 25 [26 27 28 29 30 30a - - - - - 31 32] 33 34 35 6 8 7 23 24 25 [26 27 28 29 30 - - - - - - 31 32] 33 34 35 2 7 6 Rei, Pot 23 24 25 [26 27 28 29 30 - - - - - - - 32] 33 34 35 1 6 5 J539 IMGT FR1-IMGT CDR1-IMGT FR2-IMGT unique C W numbering [1] 23 24 25 26 [27 28 29 30 31 32 33 34 35 36 37 38] 39 40 41 CDR CDR1- length[2] IMGT[1] * * * * * * * * * * * IGLV [2] 23 [24 25 26 27 27A 27B 27C - - - 28 29 30 31 32 33 34] 35 14 9 and V-LAMBDA 23 [24 25 26 27 27A 27B - - - - 28 29 30 31 32 33 34] 35 13 8 23 [24 25 26 27 27A - - - - - 28 29 30 31 32 33 34] 35 12 7 23 [24 25 26 27 - - - - - - 28 29 30 31 32 33 34] 35 11 6 L1"canonical L1 CDR1- Example structure" length[5] IMGT[1] of proteins * * * * * * * * * * IGLV [3] 23 24 25 [26 27 28 29 30 30a 30b 30c - - 31 32] 33 34 35 10 9 Newm and V-LAMBDA 23 24 25 [26 27 28 29 30 30a 30b - - - 31 32] 33 34 35 9 8 Kol, Rhe [5] 23 24 [25 26 27 28 29 30 30a 30b 30c - - 31 32] 33 34 35 2,3 11 9 Newm,Cha255 23 24 [25 26 27 28 29 30 30a 30b - - - 31 32] 33 34 35 1 10 8 Kol, Rhe 23 24 [25 26 27 - - 30 30a 30b - - - 31 32] 33 34 35 4 8 6 Hil
Colors are according to IMGT color menu for CDR-IMGT.
The CDR1-IMGT of Hil is 6 AA long. In [5], the L1 length of Hil should be 8 (instead of 9).
Indeed, in that publication, the position 30c should be 31 (there is no need of '30c').
| [1] | Lefranc, M.-P., The Immunologist, 7, 132-136 (1999). |
| [2] | Kabat, E.A. et al., In: Sequences of Proteins of Immunological Interest, NIH Publication, 91-3242 (1991). |
| [3] | Chothia, C. and Lesk, A.M., J. Mol. Biol., 196, 901-917 (1987). |
| [4] | Chothia, C. et al., Nature, 342, 877-883 (1989). |
| [5] | Al-Lazikani, B. et al., J. Mol. Biol., 273, 927-948 (1997). |
Last updated: Friday, 22-Sep-2023 18:14:34 CEST
Author: Lisa Truong
Editor: Chantal Ginestoux
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