• Version 3.1.40 (02 October 2023)
  • Internal update for the Chromosomal localization
• Version 3.1.39 (24 January 2023)
  • Internal update for the Chromosomal localization
• Version 3.1.38 (8 November 2022)
  • Update of the "IMGT Repertoire links" section in IMGT/GENE-DB entries of V genes with F+ORF+in-frame P alleles : addition of a link to [CDR1-IMGT.CDR2-IMGT.CDR3-IMGT] lengths for V genes per species and locus.
    

• Version 3.1.37 (6 June 2022)
  • Update of the List of direct links to query IMGT/GENE-DB.
    

• Version 3.1.36 (2 May 2022)
  • Internal update for the Chromosomal localization (2/2).

• Version 3.1.35 (3 March 2022)
  • Internal update for the Chromosomal localization (1/2).

• Version 3.1.34 (31 May 2021)
  • Update of the generation of FASTA sequences: update of the evaluation of the partiality in case of reverse complementary sequences for out-of-frame pseudogenes.

• Version 3.1.33 (22 March 2021)
  • Update of IMGT/GENE-DB direct links for genes of a Group.

• Version 3.1.32 (17 March 2021)
  • LOCALIZATION IN GENOME ASSEMBLIES: correction of a bug for the display of L-V-GENE-UNIT.

  • Correction of a bug for the display of the IMGT/GENE-DB Documentation.

• Version 3.1.31 (16 December 2020)
  • IMGT/GENE-DB DETAILED RESULTS: correction of a bug when reloading the form.

• Version 3.1.30 (18 September 2020)
  • LOCALIZATION IN GENOME ASSEMBLIES: update of the display for "IMGT gene orientation" and "IMGT label positions".

• Version 3.1.29 (27 July 2020)
  • RESULTS OF YOUR SEARCH: IMGT label extraction from IMGT/LIGM-DB reference sequences (F+ORF+all P): update of sequence extraction for 5'D-RS-to-3'D-RS and J-RS-to-J-REGION.

• Version 3.1.28 (17 July 2020)
  • IMGT/GENE-DB entry : update of External links, addition of links to Ensembl for Homo sapiens (human) genes.

  • IMGT/GENE-DB direct links: update of "Links to IMGT/GENE-DB and generalist genomic databases" html and csv pages, addition links to Ensembl and UniProt for Homo sapiens (human) genes.

• Version 3.1.27 (15 July 2020)
  • IMGT/GENE-DB statistics: update of the evaluation of the number of genes and alleles: TRAV/DV genes and alleles belonging to both TRAV and TRDV groups are counted only once in total number of TR genes and alleles.

  • IMGT/GENE-DB direct links: update of "Links to IMGT/GENE-DB and generalist genomic databases" html and csv pages.

• Version 3.1.26 (14 January 2020)
  • IMGT/GENE-DB entry: update of external links to ENA and GenAtlas.

• Version 3.1.25 (13 January 2020)
  • Internal improvements for the display of FASTA sequences.

• Version 3.1.24 (17 September 2019)
  • Untranslated EX4 exons of TRAC and TRDC genes are renamed EX4UTR.
    
  • Update of a bug in position for "IMGT label extraction from IMGT/LIGM-DB reference sequences"

• Version 3.1.23 (19 June 2019)
  • RESULTS OF YOUR SEARCH > Complete IMGT/GENE-DB entries > IMGT/GENE-DB DETAILED RESULTS:
    - Table "Other sequences from the literature": The columns "IMGT gene functionality and "Secondary Accession number" are not indicated.
    - Annotated IMGT/3Dstructure-DB structures and IMGT/2Dstructure-DB amino acid sequences: the number of results is shown.

• Version 3.1.22 (3 April 2019)
  • Correction of a bug to get direct links .

• Version 3.1.21 (17 January 2019)
  • "LOCALIZATION IN GENOME ASSEMBLIES": correction of a bug for the display of Canis lupus familiaris|boxer (dog) IGL locus.

• Version 3.1.20 (14 December 2018)
  • Update of links to HGNC.

• Version 3.1.19 (21 June 2018)
  • "LOCALIZATION IN GENOME ASSEMBLIES": modification of the display of tables, see the IMGT/GENE-DB Documentation.
    
  • "RESULTS OF YOUR SEARCH", "Choose your display": update of "IMGT label extraction from IMGT/LIGM-DB reference sequences (F+ORF+all P)".
    Correction of a bug for the extraction of artificially spliced exons of the Homo sapiens IGHG3 gene and other IGHC constant genes.
  • IMGT/GENE-DB individual entry: the allele functionality is not anymore indicated in table "Other sequences from the literature" as it was reported automatically and could lead to errors.
    

• Version 3.1.18 (29 November 2017)
  • Update of "LOCALIZATION IN GENOME ASSEMBLIES" tables:
    - For V genes: only V-GENE-UNIT (when available) and V-REGION positions in genome assemblies are displayed.
    - NCBI Symbol is replaced by NCBI Gene ID.
    

• Version 3.1.17 (26 July 2017)
  • Minor changes. Update of IMGT/GENE-DB header pages.
    

• Version 3.1.16 (14 December 2016)
  • IMGT/GENE-DB individual entry: update of the link to "Table of annotated IMGT/3Dstructure-DB structures and IMGT/2Dstructure-DB amino acid sequence".
    

• Version 3.1.15 (8 December 2016)
  • IMGT/GENE-DB individual entry, External links: Addition of a new section "Protein database"
    107 UniProt cross-references have been integrated (see IMGT/GENE-DB data updates).
    

• Version 3.1.14 (24th November 2016)
  • IMGT/GENE-DB Query page:
    'Locus' allows the selection on IG or TR loci (includes main loci and chromosomal orphon sets).
    'Main Locus' allows the selection on a main IG or TR locus.
  • List of resulting genes :
    The column 'Molecular component" is added on the right of the table.
    

• Version 3.1.13 (5th September 2016)
  • Minor changes (mostly broken URLs)

• Version 3.1.12 (1st July 2016)
  • IMGT/GENE-DB entry: improvement of the evaluation of the list "Annotated IMGT/LIGM-DB cDNA sequences" and "Annotated IMGT/LIGM-DB rearranged genomic DNA sequences".
  • IMGT/GENE-DB allele reference sequences in FASTA format, FASTA header: update of the reading frame (field 8), for sequences without gaps and which are partial in 5'.
  • IMGT/GENE-DB allele reference sequences in FASTA format, FASTA header: update of the reading frame (field 8) for out-of-frame pseudogenes. The reading frame is identical to the one indicated for the corresponding label in IMGT/LIGM-DB.

• Version 3.1.11 (8 February 2016)
  • FASTA format of IMGT/GENE-DB reference sequences: display in the field 6 of the header of the nucleotide(s) added in 3' of a label to obtain the complete genomic sequence (for example for J-REGION reference sequence from cDNA): the end position is followed by a comma and the added nucleotides in 3'. See for example the reference sequences of Homo sapiens TRAJ47*02 allele. Note the number of added nucleotides in 3' is indicated in field 10.

• Version 3.1.10 (16 December 2015)
  • "RESULTS OF YOUR SEARCH", "Choose your display": updates of "IMGT label extraction from IMGT/LIGM-DB reference sequences (F+ORF+all P)":
    • Potential new artificially spliced labels for IGH genes to be extracted, provided that all labels are described in a same IMGT/LIGM-DB reference sequence accession number.
      Artificially spliced exons with CHS and artificially spliced exons with membrane exon(s):
      - CH1+H+CH2+CH3+CHS, CH1+H+CH2+CH3+M1+M2
      - CH1+H+CH2+CH3+CHS, CH1+H+CH2+CH3+M
      - CH1+H1+H2+CH2+CH3+CHS, CH1+H1+H2+CH2+CH3+M1+M2
      - CH1+H1+H2+H3+H4+CH2+CH3+CHS, CH1+H1+H2+H3+H4+CH2+CH3+M1+M2
      - CH1+CH2+CH3+CH4+CHS, CH1+CH2+CH3+CH4+M1+M2

• Version 3.1.9 (16 November 2015)
  • "RESULTS OF YOUR SEARCH", "Choose your display": updates of "IMGT label extraction from IMGT/LIGM-DB reference sequences (F+ORF+all P)":
    • Correction of a bug for the extension of a given number of nucleotides in 5' and/or in 3' of selected simple labels.
    • Correction of a bug for the extraction of at least 2 of the combined labels: L-PART1-to-V-EXON, L-PART1-to-V-RS, V-EXON-to-V-RS (see IMGT label extraction from IMGT/LIGM-DB reference sequences)
    • The extension of a given number of nucleotides in 5' and/or in 3' of selected labels is only allowed for not combined labels. Therefore, for combined labels (for example: L-PART1-to-V-EXON or L-PART1+L-PART2), added numbers of nucleotides to in 5' and/or in 3' are automatically set to 0.
    • Only coding labels can be translated in amino acid sequences
    • The extension of a given number of nucleotides in 5' and/or in 3' of selected labels is only allowed for nucleotide extraction and not for amino acid translation . Therefore, for combined labels (for example: L-PART1-to-V-EXON or L-PART1+L-PART2), added numbers of nucleotides to in 5' and/or in 3' are automatically set to 0.
    • Begin and end positions are indicated for athe combined labels: L-PART1-to-V-EXON, L-PART1-to-V-RS, V-EXON-to-V-RS.
    • Update of the generated list of artificially spliced exons for C genes and alleles.

  • IMGT/GENE-DB entry: the number of "Annotated IMGT/3Dstructure-DB structures and IMGT/2Dstructure-DB amino acid sequences" is evaluated per gene.

• Version 3.1.8 (12 October 2015)
  • IMGT/GENE-DB entry: update of the link to get the "Annotated IMGT/3Dstructure-DB structures and IMGT/2Dstructure-DB amino acid sequences"

• Version 3.1.7 (22 July 2015)
  • Add of a new form to display all the localizations in genome assemblies for a given locus
  • Correction of column shift between header and rows in table "Other sequences from the literature" when consulting multiple entries

• Version 3.1.6 (9 June 2015)
  • Add of table "localizations in genome assemblies" for each entry
  • Add of column "entry type" in table "annotated IMGT/3Dstructure-DB structures and IMGT/2Dstructure-DB amino acid sequences"

• Version 3.1.5 (22 May 2015)
  • Correction of access to statistics page.
  • Display the 'strain/breed/isolate' column in the IMGT reference alleles table of each entry.

• Version 3.1.4 (5 March 2015)
  • Correct bug in the retrieval of 'Artificially spliced exon(s)' sequences for C-GENE.

• Version 3.1.3 (7 November 2014)
  • Update of the direct link for the IMGT/GENE-DB entry.

• Version 3.1.2 (28 July 2014)
  • Display of an explicit message if the direct links give no results.

• Version 3.1.1 (30 June 2014)
  • Secondary accession numbers are not shown in "Other sequences from the literature".
  • Update of the generation of IMGT/GENE-DB reference sequences in FASTA format "IMGTGENEDB-ReferenceSequences.fasta-nt-WithoutGaps-F+ORF+allP" available on IMGT downloads.

• Version 3.1.0 (4 April 2014)
  • Update of direct links: request on 'Mus' allowed (example: http://www.imgt.org/genedb/GENElect?query=7.5+IGHV&species=Mus).

• Version 3.0.0 (2 May 2013)
  • Delivered a completely new interface based on Struts2. Some loadings should now be shorter.

• Version 2.0.5 (13 December 2012)
  • Update of the table of "IMGT reference alleles" for the display of secondary accession numbers.

• Version 2.0.4 (19 November 2012)
  • Update of program and interfaces for the management of RPI genes and alleles.

• Version 2.0.3 (29 August 2012)
  • Update of program for the management a number of alleles >100.

• Version 2.0.2 (16 July 2012)
  • Update of IMGT Repertoire links.

• Version 2.0.1 (1 June 2012)
  • Update of program and interfaces for the management of conventional genes.

• Verion 2.0.0 (23 April 2012)
  • Update of statistics table for TR genes and alleles.

• 16 April 2012
  • Update of the IMGT/GENE-DB Query page:
    • The search criteria are organized according to the axioms IDENTIFICATION, LOCALIZATION and CLASSIFICATION of IMGT-ONTOLOGY.
    • Addition of new search criteria:
      - MolecularComponent (IDENTIFICATION)
      - Locus (LOCALIZATION): includes main loci and chromosomal orphon sets
      
    • Main locus: "all" value allows to search genes of all main loci.
    • Chromosomal orphon set: "all" value allows to search genes of all chromosomal orphon sets.
  • IMGT/GENE-DB Query page: TRAV/DV genes can be searched through requests on TRAV or TRDV groups and/or TRAV or TRDV subgroups.
  • IMGT/GENE-DB entry:
    • The dates of creation and of the last updated are indicated on the top right of each IMGT/GENE-DB entry.
    • For TRAV/DV genes, both TRA locus and TRD locus are indicated in "Chromosomal localization" section.
    • In the "IMGT reference alleles" table, the title of the "Strain" column, if any, is modified according to the species (for example 'Strain' for Mus musculus, 'Isolate' for Oncorhynchus mykiss, 'Breed' for Canis lupus familiaris ).
  • Update of the IMGT/GENE-DB statistics:
    • Statistics are provided for all species
    • For each species, statistics include a table for the "Number of TR genes and alleles per IMGT group" and a table for the "Number of TR functional (F), open reading frame (ORF) and pseudogene (P) alleles per IMGT group"
    - Update of the FASTA header of the IMGT/GENE-DB reference sequences: see details in data updates.

• 19 January 2012
  • Display of the comments associated to the external cross-references, if any.

• 2 December 2011
  • Addition of a link to IMGT/2Dstructure-DB entries: it is available through the "Annotated IMGT/3Dstructure-DB structures and IMGT/2Dstructure-DB amino acid sequences" section at the bottom of the IMGT/GENE-DB entry.

• 29 July 2011
  • Addition of a "direct link" to get the links to IMGT/GENE-DB and generalist genomic databases for human or mouse IG genes.
  • Addition of a "direct link" to get the links to IMGT/GENE-DB and generalist genomic databases for human ot mouse TR genes.
    See the section Links to IMGT/GENE-DB and generalist genomic databases in the "IMGT/GENE-DB direct links" page

• 28 July 2011
  • Update of the links to GeneCards

• 14 April 2011
  • Correction of a bug related to the extraction of labels H+CH2, CH3+CH-S and CH4+CH-S

• 1 March 2011
  • Update of the link to NCBI Gene
• 14 December 2010
  • Correction of a bug related to the extraction of labels that include " ' " in their name (for example 5'D-HEPTAMER) with the direct links.
  • The labels : L-V-GENE-UNIT, V-GENE-UNIT, J-GENE-UNIT and D-GENE-UNIT can be extracted.

• 9 December 2009
  • Correction of a bug in the translation of Rattus norvegicus IGKV genes and alleles.

• 26 January 2009
  • Addition of links to Vega for Homo sapiens IG genes.

• 5 December 2008
  • Sequences in FASTA format :update of the header: The FASTA header contains 15 fields separated by '|':

    * IMGT/LIGM-DB accession number(s)
    * gene and allele name
    * species
    * functionality
    * exon(s), region name(s), or extracted label(s)
    * start and end positions in the IMGT/LIGM-DB accession number(s)
    * number of nucleotides in the IMGT/LIGM-DB accession number(s)
    * codon start, or 'NR' (not relevant) for non coding labels
    * +n: number of nucleotides (nt) from an upstream donor exon, added in 5' of an exon, to obtain a complete first codon (for C-GENE exons if splicing frame 1 or 2)
    * -n: number of nucleotides (nt) deleted in 3' of an exon, to obtain a complete last codon (for C-GENE exons if splicing frame 1 or 2)
    * +n, -n, and/or nS: number of added, deleted, and/or substituted nucleotides to correct sequencing errors, or 'not corrected' if non corrected sequencing errors
    * number of amino acids (AA): this field indicates that the sequence is in amino acids
    * number of characters in the sequence: nt (or AA)+IMGT gaps=total
    * partial (if it is)
    * reverse complementary (if it is)
    

  • Update of the IMGT/GENE-DB direct links page.
  • Update of the IMGT/GENE-DB entry.

• 26 January 2009
  • Addition of links to Vega for Homo sapiens IG genes.

• 9 December 2009
  • Correction of a bug in the translation of Rattus norvegicus IGKV genes and alleles.

References to cite: Lefranc, M.-P. et al., Nucleic Acids Res., 27:209-212 (1999); doi: 10.1093/nar/27.1.209 Full text Cover; Ruiz, M. et al., Nucleic Acids Res., 28:219-221 (2000); doi: 10.1093/nar/28.1.219 Full text; Lefranc, M.-P., Nucleic Acids Res., 29:207-209 (2001); doi: 10.1093/nar/29.1.207 Full text; Lefranc, M.-P., Nucleic Acids Res., 31:307-310 (2003); doi: 10.1093/nar/gkg085 Full text; Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5:45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33:D593-597 (2005); doi: 10.1093/nar/gki065 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 37:D1006-1012 (2009); doi: 10.1093/nar/gkn838 Full text; Lefranc, M.-P. et al., Nucleic Acids Res., 43:D413-422 (2015); doi: 10.1093/nar/gku1056 Full text.

Created: 31/01/2003

Last updated: 02/10/23

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