Gene exon/intron splicing sites: Human immunoglobulin constant genes IGHC

Gene exon/intron organization: Human immunoglobulin constant genes IGHC

For more information, see Gene tables and Alignments of alleles (IMGT Repertoire).

IGHC
gene
and
allele name
(1)		 5' exon 3' exon codon_start
Exons Last
complete
codon (2)		 Codon
resulting
from
splicing		 First
complete
codon (2)		 Exons
IGHA1*01 (3)   (A) 1.3
S
TCC		 CH1 3
G CA
CH1 124
P
CCA		 (V) 2
P
CCC		 H+CH2 3
G TT
H+CH2 124
S
TCC		 (G) 1.3
N
AAC		 CH3 3
G GA
CH3 (4) 125
A
GCG		 (G) 2
S
TCT		 M 3
G GC
IGHA2*01 (3)   (A) 1.3
S
TCC		 CH1 3
G CA
CH1 124
P
CCA		 (V) 2
P
CCC		 H+CH2 3
G TT
H+CH2 124
S
TCC		 (G) 1.3
N
AAC		 CH3 3
G GA
CH3 (4) 125
A
GCG		 (G) 2
S
TCT		 M 3
G GC
IGHD*01 (3)   (A) 1.3
P
CCC		 CH1 3
G CA
CH1 124
P
CCA		 (E) 2
S
TCT		 H1 3
G AG
H1 34
T
ACA		 (G) 2
R
AGA		 H2 3
G GA
H2 24
P
CCA		 (E) 1.6
G
TGT		 CH2 3
G AG
CH2 124
P
CCC		 (A) 1.2
A
GCG		 CH3 3
G CT
CH3 124
S
AGC		 T (Y)
AT		 2
V
GTA		 CHS 3
(Y)
AC		 2
L
CTG		 M1
M1 53
K
AAG		   1
V
GTG		 M2 1
IGHE*01 (3)   (A) 1.3
S
TCC		 CH1 3
G CC
CH1 122
S
AGC		 (E) 1.6
C
TGC		 CH2 3
G TC
CH2 125
A
GCA		 (D) 1.4
S
TCC		 CH3 3
G AT
CH3 125
S
AGC		 (G) 1.3
P
CCG		 CH4 3
G GC
CH4 (4) 125
P
CCC		 (E) 2
L
CTG		 M1 3
G AG
M1 41
M
ATG		   1
V
GTG		 M2 1
IGHG1*01 (3)   (A) 1.3
S
TCC		 CH1 3
G CC
CH1 121
V
GTT		 (E) 2
P
CCC		 H 3
G AG
H 15
P
CCA		 (A) 1.5
P
CCT		 CH2 3
G CA
CH2 125
K
AAA		 (G) 1.3
Q
CAG		 CH3 3
G GG
CH3 (4) 125
P
CCG		 (E) 2
L
CTG		 M1 3
G AG
M1 44
K
AAG		   1
V
GTG		 M2 1
IGHG2*01 (3)   (A) 1.3
S
TCC		 CH1 3
G CC
CH1 121
V
GTT		 (E) 2
R
CGC		 H 3
G AG
H 12
P
CCA		 (A) 1.5
P
CCA		 CH2 3
G CA
CH2 125
K
AAA		 (G) 1.3
Q
CAG		 CH3 3
G GG
CH3 (4) 125
P
CCG		 (E) 2
L
CTG		 M1 3
G AG
M1 44
K
AAG		   1
V
GTG		 M2 1
IGHG3*01 (3)   (A) 1.3
S
TCC		 CH1 3
G CT
CH1 121
V
GTT		 (E) 2
L
CTC		 H1 3
G AG
H1 17
P
CCA		 (E) 2
P
CCC		 H2 3
G AG
H2 15
P
CCA		 (E) 2
P
CCC		 H3 3
G AG
H3 15
P
CCA		 (E) 2
P
CCC		 H4 3
G AG
H4 15
P
CCA		 (A) 1.5
P
CCT		 CH2 3
G CA
CH2 125
K
AAA		 (G) 1.3
Q
CAG		 CH3 3
G GA
CH3 (4) 125
P
CCG		 (E) 2
L
CTG		 M1 3
G AG
M1 44
K
AAG		   1
V
GTG		 M2 1
IGHG4*01 (3)   (A) 1.3
S
TCC		 CH1 3
G CT
CH1 121
V
GTT		 (E) 2
S
TCC		 H 3
G AG
H 12
P
CCA		 (A) 1.5
P
CCT		 CH2 3
G CA
CH2 125
K
AAA		 (G) 1.3
Q
CAG		 CH3 3
G GG
CH3 (4) 125
L
CTG		 (E) 2
L
CTG (5)		 M1 3
G AG (5)
M1 44
K
AAG (5)		   1
V
GTG (5)		 M2 1
IGHGP*01 (3)   (A) 1.3
S
TCC		 CH1 3
G CC
CH1 121
V
CTT		 (E) 2
P
CCC		 H 3
G AG
H 17
A
GCA		 (A) 1.5
T
ACT		 CH2 3
A CA
CH2 125
K
AAA		 (G) 1.3
Q
CAG		 CH3 3
G GG
CH3 (4) 125
P
CCG		 (E) 2
L
CTG		 M1 3
G AG
M1 44
K
AAG		   1
V
GTG		 M2 1
IGHM*01 (3)   (G) 1.3
S
AGT		 CH1 3
G GG
CH1 124
P
CCA		 (V) 1.4
I
ATT		 CH2 3
G TG
CH2 127
P
CCC		 (D) 1.3
Q
CAA		 CH3 3
G AT
CH3 125
K
AAG		 (G) 1.4
V
GTG		 CH4 3
G GG
CH4 (4) 125
T
ACC		 (E) 2
G
GGG		 M1 3
G AG
M1 39
K
AAG		   1
V
GTG		 M2 1

IMGT notes:
(1)Only allele *01 is shown. The IGHEP1 pseudogene is not included in this table.
(2)Position of the last complete codon of the 5' exon and that of the first complete codon of the 3' exon are according to the IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.
(3)The last nucleotide G of the IGH J-REGION, part of the codon resulting from the splicing with CH1, is indicated for each IGHC gene.
(4)The donor splice of the 5' exon is an internal donor splice (INT-DONOR-SPLICE) involved in the splicing of the IGH membrane chain transcript. IMGT Education>Tutorials>Immunoglobulins and B cells>Molecular genetics of immunoglobulins>Figure 7
(5)Defined by homology with the other IGHG genes. Needs to be confirmed by sequencing.

Created: 11/08/2003
Author: Marie-Paule Lefranc
Editor: Laurent Douchy