IMGT Repertoire (IG and TR)

✤ : NCBI accession number that correspond to a previously internal IMGT accession number. See the correspondence table.

IMGT notes: ↑

1. truncated pseudogene not assigned to subgroups with functional genes
2. No L-PART1, frameshift in V-REGION: several insertions and deletions
3. STOP-CODON in L-PART1
4. STOP-CODON in L-PART1, too many frameshifts
5. no L-PART1, frameshift in FR1-IMGT: insertion of 16 nt
6. no L-PART1, no L-PART2
7. STOP-CODON in L-PART1, frameshifts in V-REGION: several insertions and deletions
8. frameshift in L-PART1 causing defectuous DONOR-SPLICE, frameshifts in V-REGION: several insertions and deletions
9. no L-PART1, frameshifts in V-REGION: several insertions and deletions
10. no L-PART1, frameshift in V-REGION: insertion of 16 nt in FR1-IMGT
11. no L-PART1, no L-PART2, truncated pseudogene not assigned to subgroups with functional genes
12. frameshift in V-REGION: several insertions and deletions
13. frameshifts in V-REGION: several insertions and deletions
14. STOP-CODON in V-REGION: position 95
15. no L-PART1, frameshift in V-REGION: deletion of 1 nt in CDR1-IMGT
16. no L-PART1, no L-PART2, truncated pseudogene not assigned to subgroups with functional genes, frameshift in V-REGION: deletion of 1 nt in CDR1-IMGT
17. no L-PART1, no L-PART2, frameshifts in V-REGION: several insertions and deletions
18. No L-PART1, frameshift in L-PART2, frameshift in V-REGION: several insertions and deletions, No V-RS
19. no L-PART1+frameshift in L-PART2+too many frameshifts+no V-RS
20. STOP-CODON in FR1-IMGT, frameshift in V-REGION: several insertions and deletions in FR3-IMGT, no V-NONAMER
21. STOP-CODON in FR1-IMGT: position 1 and 15, frameshift in V-REGION: several insertions and deletions in FR3-IMGT
22. no INIT-CODON: Ile instead of Met, no ACCEPTOR-SPLICE, frameshifts in V-REGION: several insertions and deletions
23. No L-PART1, deletion of 24 nt in V-REGION, frameshift in V-REGION: several insertions and deletions
24. frameshift in V-REGION: several insertions and deletions, no V-NONAMER
25. frameshift in L-PART1: deletion of 1 nt causing defectuous DONOR-SPLICE, frameshifts in V-REGION: several insertions and deletions
26. No L-PART1, frameshift in V-REGION: several insertions and deletions, no V-NONAMER
27. No L-PART1, No L-PART2, frameshift in V-REGION: several insertions and deletions, no V-NONAMER
28. no INIT-CODON: Leu instead of Met, STOP-CODON in L-PART1, frameshift in V-REGION: insertion of 8 nt in FR1-IMGT
29. no L-PART1, no L-PART2, truncated pseudogene not assigned to subgroups with functional genes, no V-NONAMER
30. several STOP-CODON in V-REGION, frameshifts in V-REGION: several insertions and deletions
31. L-PART1 not found, frameshifts in FR3-IMGT
32. no INIT-CODON: Val instead of Met, frameshift in L-PART1:deletion of 1 nt causing defectuous DONOR-SPLICE, frameshift in V-REGION: insertion of 2 nt in FR3-IMGT
33. no L-PART1, truncated pseudogene not assigned to subgroups with functional genes, no V-RS
34. frameshifts in V-REGION, L-PART1 not found
35. no DONOR-SPLICE, frameshift in V-REGION: deletion of 2 nt in FR1-IMGT
36. frameshift in L-PART1 causing defectuous DONOR-SPLICE, no L-PART2, truncated pseudogene not assigned to subgroups with functional genes
37. frameshift in L-PART1 causing defectuous DONOR-SPLICE, no L-PART2, no L-PART2, truncated pseudogene not assigned to subgroups with functional genes
38. Frameshift in L-PART1, frameshift in V-REGION: several insertions and deletions, no V-RS
39. STOP-CODON in L-PART1, truncated pseudogene not assigned to subgroups with functional genes
40. no L-PART2, truncated pseudogene not assigned to subgroups with functional genes, no V-NONAMER
41. no L-PART1, no L-PART2, truncated pseudogene not assigned to subgroups with functional genes, truncated pseudogene not assigned to subgroups with functional genes, no V-RS
42. no L-PART1, no L-PART2, no L-PART2, truncated pseudogene not assigned to subgroups with functional genes, truncated pseudogene not assigned to subgroups with functional genes, no V-RS,
43. frameshift in L-PART2, no L-PART1, truncated pseudogene not assigned to subgroups with functional genes, no V-RS
44. V-CLUSTER: A.
45. V-CLUSTER: B.
46. V-CLUSTER: C.
47. frameshift in L-PART1, frameshift in L-PART2, frameshift in V-REGION: several insertions and deletions, no V-RS.
48. IGLV(IV)-66-1 has been identified in D87004 by IMGT curators (Folch, G., Giudicelli, V. and Lefranc, M.-P., IMGT On-line, 14/12/1999).
49. An additional vestigial pseudogene lambdavg3, which has 92% identity with lambdavg2 has been identified in D86994 by IMGT curators (N. Bosc, M.-P. Lefranc), between IGLV3-25 and IGLV3-26 (5.7kb downstream from IGLV3-26). The lambdavg2 and lambdavg3 sequences define a new clan IGLV(VI) and are designated as IGLV(VI)-22-1 (X71351)[18] and IGLV(VI)-25-1 (D86994)[26], respectively.
50. The highly diverged vestigial pseudogene lambdavgl (X99568)[5] has no CONSERVED_TRP and no 2nd_CYS (confirmed with D86999[26] although this accession number contains many sequencing or typing errors). Since this lambdavg1 sequence is unique in the human genome and can therefore be used as a STS (Sequence Tagged Site)[5] , the lambdavg1 was attributed to a new clan IGLV(VII) and designated as IGLV(VII)-41-1.

IMGT references: ↑

1. Alexandre D. et al., First genomic sequence of a human Ig variable lambda gene belonging to subgroup I. Functional genes, pseudogenes and vestigial sequences are interspersed in the IGLV locus, Nucleic Acids Res, vol. 17, no. 10, 1989, pp. 3975-3975. DOI: 10.1093/nar/17.10.3975
2. Chuchana P. et al., The IGLVA gene as a STS in the human immunoglobulin lambda light chain variable gene locus (located at 22q11), Nucleic Acids Res, vol. 19, no. 17, 1991, pp. 4786-4786. DOI: 10.1093/nar/19.17.4786
3. Chu et al., Approaching an Error-Free Diploid Human Genome Assembly of East Asian Origin, (misc) bioRxivorg, 2025, DOI: 10.1101/2025.08.01.667781
4. Chu et al., Direct Submission, Computational Biology, Beijing Institute of Genomics, Chinese Academy of Sciences / China National Center for Bioinformation. Submitted (16-AUG-2025). NGDC, Beijing, 100101, China.
5. Cole,C.G. et al., Finishing the finished human chromosome 22 sequence, Genome Biol, vol. 9, no. 5, 2008, pp. R78-.
6. Frippiat J.P. and Lefranc M.P, Genomic organisation of 34 kb of the human immunoglobulin lambda locus (IGLV): restriction map and sequences of new V lambda III genes, Mol. Immunol, vol. 31, no. 9, 1994, pp. 657-670. DOI: 10.1016/0161-5890(94)90175-9
7. Giunta S. et al., Diploid T2T reference genome of the H9 human embryonic stem cell, Unpublished.
8. He et al., T2T YAO: A Telomere to telomere Assembled Diploid Reference Genome for Han Chinese, Genomics Proteomics & Bioinformatics 21(6): 1085–1100 (2023), DOI: 10.1016/j.gpb.2023.08.001
9. Kawasaki K. et al., One-megabase sequence analysis of the human immunoglobulin lambda gene locus, Genome Res, vol. 7, no. 3, 1997, pp. 250-261. PUBMED: 9074928
10. Lander,E.S. et al., Initial sequencing and analysis of the human genome, International Human Genome Sequencing Consortium Nature, vol. 409, no. 6822, 2001, pp. 860-921.
11. Liao W.W. et al., A draft human pangenome reference, Nature, vol. 617, no. 7960, 2023, pp. 312-324. PUBMED: 37165242
12. Manso T. et al., IMGT(R) databases, related tools and web resources through three main axes of research and development, Nucleic Acids Res, vol. 50, no. D1, 2022, pp. 1262-1272.
13. Nurk S. et al., The complete sequence of a human genome, Science, vol. 376, no. 6588, 2022, pp. 44-53. PUBMED: 35357919
14. Rodriguez,O.L. et al., An ethnically diverse genomic reference resource for human immune receptor gene loci, Unpublished.
15. Rodriguez O.L. et al., An ethnically diverse genomic reference resource for human immune receptor gene loci, Unpublished.