IMGT®, the international ImMunoGeneTics information system®

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A gene represents a major concept of classification in IMGT. A gene is defined as a DNA sequence that can be potentially transcribed and/or translated (this definition includes the regulatory elements in 5' and 3', and the introns, if present). The IMGT gene definition follows that given in [2]. A gene is "a hereditary unit that, in the classical sense, occupies a specific position within the genome or chromosome; a unit that has one or more specific effects upon the phenotype of the organism; a unit that can mutate to various allelic forms; a unit that recombines with other such units".

Instances of the "gene" concept are gene names. By extension, orphons and pseudogenes are also instances of the "gene" concept.

The 'gene' concept is part of the 'CLASSIFICATION' concept of IMGT-ONTOLOGY [1]

IMGT/GENE-DB is based on the 'gene' concept.

Below are listed a selection of links to IMGT Scientific chart, IMGT Repertoire, IMGT Education and IMGT Posters and diaporama which provide information on immunoglobulin (IG) and T cell receptor (TR) genes, on major histocompatibility (MH) genes, and on genes encoding related proteins of the immune system (RPI), members of the IgSF and MhSF.

IG and TR genes
IMGT Scientific chart
How to qualify a gene (Structure and localisation)
IMGT gene name nomenclature for IG and TR of human and other vertebrates
IMGT Repertoire (IG and TR)
Locus representations
Gene exon/intron organization
Gene tables
IG and TR number of genes: Human
Total number of IG and TR genes
Number of functional IG and TR genes
Number of genes in the IMGT genome analysis tools
Potential germline repertoires
List of human IG and TR genes
List of mouse (Mus musculus) IG and TR genes
Correspondence between nomenclatures
Correspondence between chain types and C genes : IG and TR (all vertebrate species)
IMGT Education (Questions and answers)
Nomenclature and overview of the human immunoglobulin genes
Nomenclature and overview of the human T cell receptor genes
Immunoglobulines. Gènes et locus (in French)
IMGT Posters and diaporama
Nomenclature and overview of the human immunoglobulin genes
Nomenclature and overview of the human T cell receptor genes
MH genes
IMGT Repertoire (MH)
IMGT/LocusView complete locus
IMGT/GeneSearch list of genes
IMGT/GeneView query
Gene exon/intron organization
Lists of MH genes and loci
Correspondence between nomenclatures
RPI genes
IMGT Repertoire (RPI)
Gene tables
Correspondence between nomenclatures
Gene exon/intron organization

[1] Giudicelli, V. and Lefranc, M.-P., Bioinformatics, 15, 1047-1054 (1999) PMID: 10745995, LIGM:221 pdf
[2] King, R.C. and Stansfield, W.D. A dictionary of genetics. Fifth edition. Oxford University Press (1997)