IMGT Repertoire (IG and TR)

Print of this table: Barbié, V. and Lefranc, M.-P., Exp. Clin. Immunogenet., 15, 171-183 (1998). PMID: 9813414

For a comparative repertoire between different assemblies' annotations, see: Human (Homo sapiens) IGK locus (on chromosome 2 on the short arm, at band 2p11.2) gene repertoire per assembly.

Distal and proximal V-CLUSTERs (for the haplotypes with both clusters).

76 IGKV genes belonging to 7 subgroups and 1 clan, on 1 800 kilobases:
- 38-43 FUNCTIONAL
- 6-7 ORF (Open Reading Frame)
- 32-36 PSEUDOGENE
- 4 FUNCTIONAL or PSEUDOGENE
- 1 FUNCTIONAL or ORF
Potential repertoire: 38-43 FUNCTIONAL IGKV genes belonging to 6 subgroups

Subgroup	Functional	ORF	Pseudogene	Total
IGKV1	20(+2)*	3	7(0:7)(+2(2:0))*	32
IGKV2	9(+1)*	1	16(3:13)(+1(1:0))*	27
IGKV3	5(+2)*	1(+1)*	6(0:6)(+1(1:0))*	14
IGKV4	1	0	0	1
IGKV5	1	0	0	1
IGKV6	2	1	0	3
IGKV7	0	0	1(0:1)	1
IGKV(II)	0	0	2(0:2)	2
Total	38(+5)*	6(+1)*	32(+4)*	81

In the column 'Pseudogene', the number of pseudogenes with V-REGION in-frame and the number of pseudogenes with frameshift(s) are shown separated by two dots, between parentheses.
* An asterisk indicates that the following genes have alleles with different functionalities:
FUNCTIONAL or PSEUDOGENE (IGKV1-13, IGKV1-39, IGKV2-29, IGKV3D-15)
FUNCTIONAL or ORF (IGKV3D-20)

Proximal V-CLUSTER (for the haplotypes without the distal V-CLUSTER)

40 IGKV genes belonging to 7 subgroups and 1 clan, on 600 kilobases:
- 20-23 FUNCTIONAL
- 2 ORF (Open Reading Frame)
- 17-20 PSEUDOGENE
- 3 FUNCTIONAL or PSEUDOGENE
Potential repertoire: 20-23 FUNCTIONAL IGKV genes belonging to 6 subgroups

Subgroup	Functional	ORF	Pseudogene	Total
IGKV1	10(+2)*	1	3(0:3)(+2(2:0))*	16
IGKV2	4(+1)*	0	9(2:7)(+1(1:0))*	14
IGKV3	3	1	3(0:3)	7
IGKV4	1	0	0	1
IGKV5	1	0	0	1
IGKV6	1	0	0	1
IGKV7	0	0	1(0:1)	1
IGKV(II)	0	0	1(0:1)	1
Total	20(+3)*	2	17(+3)*	42

Human Homo sapiens IGKJ genes

5 IGKJ genes belonging to 5 sets:
- 4-5 FUNCTIONAL
- 0-1 ORF (Open Reading Frame)
- 0 PSEUDOGENE
Potential repertoire: 4-5 FUNCTIONAL IGKJ genes belonging to 5 sets

IMGT set or subgroup (if any)	Functional	ORF	Total
IGKJ1	1	0	1
IGKJ2	1	0	1
IGKJ3	1	0	1
IGKJ4	(+1)*	(+1)*	1
IGKJ5	1	0	1
Total	4(+1)*	(+1)*	5

* An asterisk indicates that the following genes have alleles with different functionalities:
FUNCTIONAL or ORF (Open Reading Frame) (IGKJ4).

IMGT Repertoire (IG and TR)

Number of germline genes and potential repertoire: Human (Homo sapiens) IGKV at 2p11.2

Distal and proximal V-CLUSTERs (for the haplotypes with both clusters).

Proximal V-CLUSTER (for the haplotypes without the distal V-CLUSTER)

Human Homo sapiens IGKJ genes