The genomic organization of the HLA-DR genes, in the human MHC locus on chromosome 6p21.3, is displayed with the DR serological families which are encoded by the HLA-DRB3/4/5 gene and the HLA-DRB1 gene, respectively.
Examples of HLA-DR3/4/5 and HLA-DRB1 alleles found in the different HLA-DR haplotypes are indicated below the gene representations.
The localization of the HLA-DR genes is from position 2693617 (HLA-DRA 5' end)
to position 2820421 (HLA-DRB1 3' end), on chromosome 6p21.3, according to
IMGT/GeneSearch, IMGT/GeneView, IMGT/LocusView, based on the Sanger
MHC list of May 2000 (complete sequencing of the locus).
The MHC Haplotype Project will allow to specify the positions of the HLA-DR genes in different haplotypes .
|DR serological families encoded by the HLA-DRB3/4/5 alleles||DR serological families encoded by the HLA-DRB1 alleles||
Genomic organization (on chromosome
|none||DR1, 10, 103|
|DR51||DR2, 15, 16|
|DR52||DR3, 17, 18
DR5, 11, 12
DR6, 13, 14, 1403, 1404
|(1)||Pseudogenes are not shown in the genomic organization displayed in the table header.|
|||Chida S. et al., Immunogenetics, 52, 186-194 (2001) PMID: 11220620|