IMGT Repertoire (MH)

Representative MH genes and chains: human and mouse MH1, MH2 (classical and nonclassical) and RPI-MH1Like genes

1. (1) Owing to a lesser degree of polymorphism of the Homo sapiens nonclassical MH1 and MH2 genes, compared to the classical MH1 and MH2 genes, a 2-digit is used for their allele description (IMGT Scientific chart): *01 refers to *0101 found in the literature. The allele nomenclature of the highly polymorphic Homo sapiens classical MH1 and MH2 is according to HLA-DB [1]. Mus musculus MH (formerly H2) alleles are numbered starting from allele *01 (sequence from strain C57BL/6). Homo sapiens and Mus musculus RPI-MH1Like alleles are numbered starting from allele *01 that corresponds to the IMGT reference sequence (IMGT Repertoire). The Musmus MH2-PA gene (MH2-PA*01 accession number D64112, strain C57BL/6) that is a pseudogene, and the Musmus MH2-PB gene that has not yet been identified, are not included in the table.
2. (2) GEDI (GenBank, EMBL-Bank, DDBJ, IMGT/LIGM-DB) nucleotide sequence accession numbers. gDNA: genomic DNA; cDNA: complementary DNA.
3. (3) From "Mouse MH haplotypes and polymorphisms" [2,3].
4. (4) Chain codes from IMGT/3Dstructure-DB [4]. The code is shown within parentheses for 3D structures in which the chain sequence differs from the translation of the corresponding representative allele in column 3.
5. (5) Accession numbers that were necessary for splicing site identification: "same allele" refers to the allele in column 3, "other alleles" refers to alleles other than the ones in column 3.

1. [1] Ruiz, M. et al., Nucleic Acid. Res., 28, 219-221 (2000), LIGM:224 . PMID:20063264
2. [2] Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005), LIGM:291 . PMID:15608269
3. [3] Lefranc, M.-P. et al., In Silico Biology, 2005, 5, 45-60, Epub 2005, 5, 0006, 24 Dec 2004, LIGM:294 . PMID:15972004
4. [4] Kaas, Q. et al., Nucl. Acids. Res., 32, D208-D210 (2004), LIGM:281 . PMID:14681396

• IMGT Repertoire (MH)
  • IMGT protein display G-DOMAIN
  • IMGT protein display C-LIKE-DOMAIN
  • IMGT Collier de Perles G-DOMAIN
  • IMGT Collier de Perles C-LIKE-DOMAIN
  • Strand and loop lengths
• IMGT Index
  • allele
  • haplotype
• IMGT Education (FR)
  • Présentation globale du complexe majeur d'histocompatibilité
  • La superfamille des immunoglobulines (IgSF)
  • La superfamille du complexe majeur d'histocompatibilité (MhSF)
• IMGT Tools
  • IMGT/Allele-Align
  • IMGT/Collier de Perles
  • IMGT/DomainGapAlign
  • IMGT/DomainDisplay
  • IMGT/3Dstructure-DB