IMGT®, the international ImMunoGeneTics information system®

logo IMGT


IMGT/HighV-QUEST[1] (V-QUERy and STandardization) is part of IMGT®, the international ImMunoGeneTics information system® [2].

IMGT/HighV-QUEST is the high-throughput version of IMGT/V-QUEST [3,4] for the analysis of thousands of immunoglobulin (IG) and T cell receptor (TR) rearranged nucleotide sequences per run.

IMGT/HighV-QUEST has been developed by IMGT®, the international ImMunoGeneTics Information System® to answer the problematic of the analysis of the antigen receptor data from Next-Generation Sequencing (NGS).

Note that:

Once registered and the submission is accepted by IMGT/HighV-QUEST administrator, users can log in into IMGT/HighV-QUEST using their e-mail and the password they selected during the registration. The first page that a user may see after logging in is the Search Page of IMGT/HighV-QUEST.

Citing IMGT:
Lefranc, M.-P. et al., "IMGT®, the international ImMunoGeneTics database®" Nucl. Acids Res, 37, D1006-D1012 (2009); doi:10.1093/nar/gkn838. PMID: 18978023 pdf

Citing IMGT/HighV-QUEST:
Alamyar, E. et al., IMGT/HighV-QUEST: A High-Throughput System and Web Portal for the Analysis of Rearranged Nucleotide Sequences of Antigen Receptors, JOBIM 2010, Paper 63 (2010). pdf
Brochet, X. et al., Nucl. Acids Res. 36, W503-508 (2008). PMID: 18503082 pdf

[1] Alamyar, E. et al., JOBIM2010, Paper 63 (2010). pdf
[2] Alamyar, E. et al., Immunome Res. 8:1:2. doi:10.4172/1745-7580.1000056. LIGM:400
[3] Alamyar, E. et al., In: B. Tait and F. Christiansen (Eds.), Immunogenetics, chap 32, Humana Press, Springer, New York, USA. Methods Mol. Biof. 882:569-604(2012). PMID:22665256 LIGM:404
[4] Li.S et al., Nat. Commun. 4:2333;2013 doi:10.1038/ncomms3333 openaccess. PMID:23995877 LIGM:419
[5] Giudicelli V., et al., Autoimmun Infec Dis. 1(1)(2015). doi: 10.16966/aidoa.103. Free Article LIGM:448
[6] M.-P. Lefranc, et al. IMGT®, the international ImMunoGeneTics information system®. Nucleic Acids Res., 37, 1006-1012 (2015). PMID:18978023 LIGM:349 PDF
[7] Giudicelli, V. et al., Nucl. Acids Res. 32, W435-440 (2004). PMID: 15215425, LIGM:287 pdf
[8] Brochet, X. et al., Nucl. Acids Res. 36, W503-508 (2008). PMID: 18503082, LIGM:344