IMGT®, the international ImMunoGeneTics information system®

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The 'interaction' concept is part of IMGT-ONTOLOGY.

The 'interaction' concept comprises the concepts of interaction that are necessary to define interactions between components at the molecule, cell, organ, organism and/or populaton level.

At the molecular level, major concepts of interaction were generated, based on the standardized concepts of classification, description and numerotation, for example:

The 'pMHC contact site' concept allows to define peptide/MHC interactions, whereas the 'IMGT Residue@Position' concept allows to define antigen/receptor and domain interactions.

[1] Kaas, Q. and Lefranc, M.-P. "T cell receptor/peptide/MHC molecular characterization and standardized pMHC contact sites in IMGT/3Dstructure-DB" In Silico Biology. Epub 2005, 5, 0046 Oct 20, 5, 505-528 (2005). PMID: 16268793
[2] Kaas, Q., Duprat, E., Tourneur, G. and Lefranc, M.-P. "IMGT standardization for molecular characterization of the T cell receptor/peptide/MHC complexes" In: Immunoinformatics (Schoenbach C., Ranganathan S. and Brusic V. eds.), Immunomics Reviews, Series of Springer Science and Business Media LLC, Springer, New York, USA chap. 2, pp.19-49 (2008)